The effects of early environment on the development of functional laterality in Morris maze performance.
The effects of early environment on the development of functional laterality in Morris maze performance.
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DOI：
10.1080/713754274
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发表时间：
1997-01-01
期刊：
影响因子：
1.4
通讯作者：
Denenberg, V H
中科院分区：
文献类型：
--
作者：
Cowell, P E;Waters, N S;Denenberg, V H
目前的研究考察了出生后早期经历对雄性大鼠空间能力功能偏侧化的贡献。在生命的前20天，处理(H)或未处理(NH)的幼崽，每只幼崽中的三只雄性在成年后在Morris水迷宫中进行测试。每窝猫中的两名受试者接受了单眼测试，其中一人的右眼戴上了眼罩，另一人的左眼戴上了眼罩。每窝中的第三个受试者在两只眼睛都睁开的情况下进行测试。处理与眼罩相互作用，以测量时间和距离。与NH组相比，右侧和左侧补丁大鼠的表现相同，但右侧补片测试的H受试者表现优于左侧补片测试的H受试者。这些结果证实了一项研究，该研究发现雄性大鼠的空间导航能力偏向于右半球。这些数据表明，成年雄性大鼠空间航行行为的功能不对称性对发育早期的环境影响很敏感。
The current study examined the contribution of early postnatal experience to the functional lateralisation of spatial ability in the male rat. Litters were handled (H) or non-handled (NH) during the first 20 days of life, and three males from each litter were tested in the Morris water maze in adulthood. Two subjects from each litter were monocularly tested, one with the right eye patched and the other with the left eye patched. A third subject in each litter was tested with both eyes open. Handling interacted with Eye Patch for time and distance measures. Performance of Right- and Left-Patched rats was equivalent for the NH group, but the H subjects tested with the Right Patch outperformed H subjects with the Left Patch. These results confirm studies that found spatial navigation performance to be lateralised to the right hemisphere in male rats. The data indicate that functional asymmetry of spatial navigation behaviour in the adult male rat is sensitive to environmental influences during early development.