Estrogen and progesterone distinctively modulate methamphetamine-induced dopamine and serotonin depletions in C57BL/6J mice
Estrogen and progesterone distinctively modulate methamphetamine-induced dopamine and serotonin depletions in C57BL/6J mice
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雌激素和孕激素显着调节 C57BL/6J 小鼠中甲基苯丙胺诱导的多巴胺和血清素消耗
DOI：
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发表时间：
2000
影响因子：
3.3
通讯作者：
P. Liao
中科院分区：
文献类型：
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作者：
L. Yu;P. Liao
总结。纹状体内注射高剂量（100 μg/3 μl）的甲基苯丙胺会导致雄性和雌性小鼠纹状体多巴胺和血清素的长期消耗。雄性小鼠表现出纹状体多巴胺和血清素比雌性小鼠更大的消耗。当系统给予4次甲基苯丙胺累积剂量时，观察到类似的性别差异趋势。因此，纹状体中甲基苯丙胺诱导的神经毒性的性别差异可能不是由于甲基苯丙胺外周代谢的差异。此外，与对照组相比，每日补充3剂量高水平或生理水平的雌二醇苯甲酸酯（EB）、每日补充3剂量黄体酮(P)、每日补充2剂量EB后再补充1剂量P的去卵巢（OVX）小鼠在甲基苯丙胺治疗后纹状体多巴胺水平均较高。每天3次P预处理的OVX小鼠在给药后纹状体血清素水平最高。结论：甲基苯丙胺诱导纹状体神经毒性的性别差异可能受到卵巢激素的调节。
Summary. Intra-striatal infusion of a high dose (100 μg/3 μl) of methamphetamine produced long-lasting depletions of striatal dopamine and serotonin in both male and female mice. Male mice exhibited a greater depletion of striatal dopamine and serotonin than female mice. A similar trend of sexual differences was observed when 4 cumulative doses of methamphetamine were administered systemically. Thus, the sexual differences in methamphetamine-induced neurotoxicity in the striatum are probably not due to their differences in peripheral metabolism of methamphetamine. Moreover, ovariectomized (OVX) mice supplemented with 3 daily doses of estradiol benzoate (EB) at high or physiological levels, 3 daily doses of progesterone (P), and 2 doses of EB followed by 1 dose of P all demonstrated higher striatal dopamine levels following methamphetamine treatment as compared to vehicle-supplemented controls. The OVX mice pretreated with 3 daily doses of P exhibited the highest striatal serotonin levels after methamphetamine administration of all groups. In conclusion, sexual differences observed in methamphetamine-induced striatal neurotoxicity may be modulated by ovarian hormones.
雌激素在仓鼠肾脏中诱导核儿茶酚-O-甲基转移酶：对雌激素诱导的肾癌的影响。
影响因子：
4.7
作者：
Weisz,J;Fritz-Wolz,G;Clawson,GA;Benedict,CM;Abendroth,C;Creveling,CR
通讯作者：
Creveling,CR