Effects of endurance training on glucose tolerance and plasma lipid levels in older men and women.
Effects of endurance training on glucose tolerance and plasma lipid levels in older men and women.
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DOI：
10.1001/jama.1984.03350050033022
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发表时间：
1984-08
期刊：
影响因子：
--
通讯作者：
D. Seals;J. Hagberg;B. Hurley;A. Ehsani;J. Holloszy
中科院分区：
文献类型：
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作者：
D. Seals;J. Hagberg;B. Hurley;A. Ehsani;J. Holloszy
11名健康男性和女性（63 +/- 1岁）参加了一项为期12个月的运动训练计划，以确定低强度和高强度训练对老年人葡萄糖耐量和血脂的影响。在摄入100 g葡萄糖后3小时测量血浆葡萄糖、胰岛素和C肽浓度，并计算各自曲线下的总面积。空腹时测定血浆总脂质和脂蛋白浓度。在六个月的低强度训练中，最大摄氧量增加了12%;在另外六个月的高强度训练中，最大摄氧量又增加了18%。最初正常的葡萄糖耐量在训练后没有显着变化。然而，与训练前相比，低强度训练后胰岛素的总面积降低了8%，高强度训练后降低了23%。C-肽浓度类似地降低。低强度训练后，血脂和脂蛋白浓度没有变化，但高强度训练导致高密度脂蛋白胆固醇增加和甘油三酯减少。这些结果表明，老年人对长时间高强度耐力训练的反应是增加对胰岛素的敏感性，并使他们的血浆脂蛋白-脂质谱发生有利的改变。
Eleven healthy men and women (63 +/- 1 years) participated in a 12-month endurance-training program to determine the effects of low-intensity and high-intensity training on glucose tolerance and plasma lipids in older persons. Plasma glucose, insulin, and C-peptide concentrations were measured for three hours after ingestion of 100 g of glucose and the total areas under the respective curves were calculated. Total plasma lipids and lipoprotein concentrations were determined during fasting. Maximal oxygen uptake increased 12% during six months of low-intensity training; a further 18% increase occurred during an additional six months of high-intensity training. Glucose tolerance, which was normal initially, was not significantly changed after training. However, the total area for insulin was 8% lower after low-intensity training, and 23% lower after high-intensity training, compared with before training. C-peptide concentrations were similarly reduced. Plasma lipid and lipoprotein concentrations were unchanged after low-intensity training, but high-intensity training resulted in an increase in high-density lipoprotein cholesterol and a reduction in triglycerides. These results demonstrate that older persons respond to prolonged, high-intensity endurance training with an increase in sensitivity to insulin and a favorable alteration in their plasma lipoprotein-lipid profile.