Immunological parameters: What do they mean?'
Immunological parameters: What do they mean?'
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DOI：
10.1093/jn/137.3.773s
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发表时间：
2007-03-01
影响因子：
4.2
通讯作者：
Calder, Philip C.
中科院分区：
文献类型：
--
作者：
Calder, Philip C.
免疫系统的作用是保护宿主免受环境中存在的感染性物质和其他有害侮辱的影响。它总是活跃的，在行动上区分“非我”和“自我”。免疫系统有两种功能：先天免疫系统和后天免疫系统。两者都涉及到各种血源性因素和细胞。有许多方法可以评估免疫功能的各个方面；其中许多方法依赖于体外培养细胞的研究。即使在健康人中，许多免疫功能也存在很大的个体间差异。许多因素，包括遗传、性别、年龄、营养状况和肠道菌群，导致了观察到的差异。免疫反应明显低于“正常”的人更容易受到感染因素的影响，并表现出更高的感染性发病率和死亡率。然而，目前还不清楚健康个体的免疫功能变化与感染易感性的变化有何关系。
The immune system acts to protect the host from infectious agents that exist in the environment and from other noxious insults. It is constantly active, acting to discriminate "nonself" from "self." The immune system has 2 functional divisions: the innate and the acquired. Both involve various blood-borne factors and cells. A number of methodologies exist to assess aspects of immune function; many of these rely on studying cells in culture ex vivo. There are large interindividual variations in many immune functions even among the healthy. Many factors, including genetics, gender, age, nutrient status, and gut flora, contribute to the observed variation. Individuals with immune responses significantly below "normal" are more susceptible to infectious agents and exhibit increased infectious morbidity and mortality. However, it is not clear how the variation in immune function among healthy individuals relates to variation in susceptibility to infection.