The relation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and mean platelet volume with the presence and severity of Behcet's syndrome
The relation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and mean platelet volume with the presence and severity of Behcet's syndrome
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DOI：
10.1016/j.kjms.2015.10.010
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发表时间：
2015-12-01
影响因子：
3.3
通讯作者：
Turkoglu, Elif Betul
中科院分区：
文献类型：
--
作者：
Alan, Sevil;Tuna, Serpil;Turkoglu, Elif Betul
白塞氏综合征(BS)与慢性炎症和内皮功能障碍有关。尽管对中性粒细胞/淋巴细胞比率(NLR)、血小板/淋巴细胞比率(PLR)和平均血小板体积(MPV)在许多疾病中的作用进行了广泛的研究，但它们在BS中的作用尚不清楚。本研究的目的是评估BS患者的NLR、PLR和MPV水平，并探讨其临床意义。这项研究包括254名BS患者和173名健康人。记录患者的年龄、性别、发病年龄、病程、吸烟、白塞氏活动评分、白细胞总数、中性粒细胞、血小板和T淋巴细胞计数。BS患者的白细胞(WBC)、中性粒细胞、血小板、中性粒细胞受体和PLR均显著高于健康对照组(均P<0.001)。BS组淋巴细胞计数和MPV与健康对照组无统计学差异(均P>；0.05)。在BS组，PLR和MPV在三个严重程度组之间有显著差异(p=0.037和p=0.016)。我们发现，任何实验室标记物都与BS的关节、眼部、中枢神经系统、大血管或胃肠道受累无关。多因素分析显示NLR是BS的独立影响因素。我们建议，考虑到更大规模的前瞻性研究结果的支持，NLR可以被认为是BS的诊断标准。版权所有(C)2015，高雄医科大学。爱思唯尔台湾有限责任公司出版。版权所有。
Behcet's syndrome (BS) is associated with chronic inflammation and endothelial dysfunction. Although there have been extensive investigations on neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) in many diseases, their roles in BS is unclear. The purpose of the present study was to evaluate NLR, PLR, and MPV levels in BS patients and explore their clinical significance. The study included 254 patients with BS and 173 healthy individuals. Age, sex, age of onset, duration of disease, smoking, Behcet activity score, total white blood counts, neutrophil, platelet, and T lymphocyte counts of the patients were recorded. White blood cell (WBC), neutrophil, platelet, NLR, and PLR were significantly higher in patients with BS when compared with healthy controls (all p < 0.001). Lymphocyte counts and MPVs of the BS group were not statistically different from healthy controls (all p > 0.05). In the BS group, PLR and MPV were significantly different among the three severity groups (p = 0.037 and p = 0.016, respectively). We showed that any laboratory markers were not associated with joint, eye, central nervous system, large vessel, or gastrointestinal involvement in BS. NLR was shown to be an independent factor for BS by multivariate analysis. We suggest that NLR can be considered to be a diagnostic criterion of BS given the support of the findings from larger prospective studies. Copyright (C) 2015, Kaohsiung Medical University. Published by Elsevier Taiwan LLC. All rights reserved.