Prevalence and significance of naturally occurring mutations in the surface and polymerase genes of hepatitis B virus
Prevalence and significance of naturally occurring mutations in the surface and polymerase genes of hepatitis B virus
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DOI：
10.1086/315094
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发表时间：
1999-11-01
影响因子：
6.4
通讯作者：
Sato, C
中科院分区：
文献类型：
--
作者：
Ogura, Y;Kurosaki, M;Sato, C
在 42 名慢性肝炎患者中分析了乙型肝炎病毒 (HBV) 全长表面和重叠聚合酶基因自然发生突变的患病率和临床意义。在 10 名患者 (24%) 的 a 决定区域中观察到突变，该区域是表面基因主要亲水区域内的中和表位。这些突变的高比例（17/18；94%）发生在第一个环，与免疫诱导的突变不同，乙型肝炎表面抗原血清抗体的存在与这些突变显着相关。表面基因的其他区域不包含任何突变簇。这些结果表明，逃逸突变通常会导致 HBV 感染自然过程中的持续存在。相比之下，根本没有检测到影响聚合酶基因主要催化结构域的突变，这些突变可能会改变抗病毒核苷类似物的敏感性。
The prevalence and clinical significance of naturally occurring mutations in the full-length surface and overlapping polymerase genes of hepatitis B virus (HBV) were analyzed in 42 patients with chronic hepatitis. Mutations were observed in 10 patients (24%) in the a determinant region, which is the neutralizing epitope within the major hydrophilic region of the surface gene. A high proportion of these mutations (17/18; 94%) occurred in the first loop, unlike mutations induced by immunization, The presence of serum antibody to hepatitis B surface antigen was significantly associated with these mutations. No other region of the surface gene contained any cluster of mutations. These results suggest that escape mutations commonly contribute to persistency in the natural course of HBV infection. In contrast, mutations affecting the major catalytic domains of the polymerase gene, which could alter susceptibility to antiviral nucleoside analogues, were not detected at all.