Cocaine-induced reduction of glucose utilization in human brain. A study using positron emission tomography and [fluorine 18]-fluorodeoxyglucose.
Cocaine-induced reduction of glucose utilization in human brain. A study using positron emission tomography and [fluorine 18]-fluorodeoxyglucose.
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DOI：
10.1001/archpsyc.1990.01810180067010
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发表时间：
1990-06
影响因子：
--
通讯作者：
E. London;N. Cascella;D. Wong;R. L. Phillips;R. Dannals;J. Links;Ronald Herning;R. Grayson;J. Jaffe;H. Wagner
中科院分区：
文献类型：
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作者：
E. London;N. Cascella;D. Wong;R. L. Phillips;R. Dannals;J. Links;Ronald Herning;R. Grayson;J. Jaffe;H. Wagner
我们在一项双盲、安慰剂对照、交叉研究中检查了盐酸可卡因（40 mg静脉注射）对8名多药滥用者局部脑葡萄糖代谢率和主观自我报告的影响。局部脑葡萄糖代谢率的测定采用[氟18]-氟脱氧葡萄糖法，使用正电子发射断层扫描。受试者蒙上眼睛，听一盘有白色噪音、“哔哔”声提示的磁带，并询问可卡因或生理盐水的主观效果。可卡因在全球范围内产生欣快感并降低葡萄糖利用率（平均降低14%）。29个脑区中的26个（所有新皮质区、基底神经节、海马结构部分、丘脑和中脑）显示局部脑葡萄糖代谢率显著降低（5%至26%）。在脑桥、小脑皮质或小脑蚓部未观察到可卡因的显著影响。右侧大于左侧半球的不对称的区域大脑葡萄糖代谢率发生在外侧丘脑。研究结果表明，大脑代谢减少与可卡因诱导的欣快感有关。
We examined the effects of cocaine hydrochloride (40 mg intravenously) on regional cerebral metabolic rates for glucose and on subjective self-reports of eight polydrug abusers in a double-blind, placebo-controlled, crossover study. The regional cerebral metabolic rate for glucose was measured by the [fluorine 18]-fluorodeoxyglucose method, using positron emission tomography. With eyes covered, subjects listened to a tape that presented white noise, "beep" prompts, and questions about subjective effects of cocaine or saline. Cocaine produced euphoria and reduced glucose utilization globally (mean reduction, 14%). Twenty-six of 29 brain regions (all neocortical areas, basal ganglia, portions of the hippocampal formation, thalamus, and midbrain) showed significant decrements (5% to 26%) in the regional cerebral metabolic rate for glucose. No significant effects of cocaine were observed in the pons, the cerebellar cortex, or the vermis. Right-greater-than-left hemispheric asymmetry of regional cerebral metabolic rates for glucose occurred in the lateral thalamus. The findings demonstrate that reduced cerebral metabolism is associated with cocaine-induced euphoria.