Frontostriatal White Matter Integrity Predicts Development of Delay of Gratification: A Longitudinal Study
Frontostriatal White Matter Integrity Predicts Development of Delay of Gratification: A Longitudinal Study
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DOI：
10.1523/jneurosci.3459-15.2016
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发表时间：
2016-02-10
影响因子：
5.3
通讯作者：
Crone, Eveline A.
中科院分区：
文献类型：
--
作者：
Achterberg, Michelle;Peper, Jiska S.;Crone, Eveline A.
在整个发展过程中，延迟满足的能力会大大增强。在这里，我们测试的假设，这种冲动控制能力是由额纹状体电路的成熟度增加，使用纤维跟踪方法结合纵向成像。总共有192名8至26岁的健康志愿者接受了弥散张量成像扫描，并完成了两次延迟折扣任务，间隔2年。我们调查了额纹状体白色物质（WM）的完整性和延迟满足技能之间的动态关联。此外，我们还研究了额纹状体WM完整性对未来延迟满足技能的预测价值。结果表明，延迟折扣随着年龄的增加，在二次时尚，最大的耐心在青春期后期。数据还表明，非线性发展的额纹状体WM，相对快速的发展在儿童期和成年早期和平均变化不大，在青春期中期。此外，年龄和延迟折扣之间的正相关性进一步增加，在个人具有较高的WM完整性的额纹状体束。预测分析表明，额纹状体WM的发展解释了独特的方差在当前和未来的延迟满足技能。这项研究增加了描述性的WM完整性和延迟满足之间的关系表明，成熟的额纹状体连接预测延迟满足技能的变化。这些发现对研究冲动控制的异常有意义，因为它们表明纹状体和前额叶皮层之间的发育路径可能是发育偏离方向的重要预测因素。
The ability to delay gratification increases considerably across development. Here, we test the hypothesis that this impulse control capacity is driven by increased maturation of frontostriatal circuitry using a fiber-tracking approach combined with longitudinal imaging. In total, 192 healthy volunteers between 8 and 26 years underwent diffusion tensor imaging scanning and completed a delay-discounting task twice, separated by a 2-year interval. We investigated dynamic associations between frontostriatal white matter (WM) integrity and delay of gratification skills. Moreover, we examined the predictive value of frontostriatal WM integrity for future delay of gratification skills. Results showed that delay discounting increases with age in a quadratic fashion, with greatest patience during late adolescence. Data also indicated nonlinear development of frontostriatal WM, with relative fast development during childhood and early adulthood and-on average-little change during mid-adolescence. Furthermore, the positive association between age and delay discounting was further increased in individuals with higher WM integrity of the frontostriatal tracts. Predictive analysis showed that frontostriatal WM development explained unique variance in current and future delay of gratification skills. This study adds to a descriptive relation between WM integrity and delay of gratification by showing that maturation of frontostriatal connectivity predicts changes in delay of gratification skills. These findings have implications for studies examining deviances in impulse control by showing that the developmental path between striatum and prefrontal cortex may be an important predictor for when development goes astray.