G-protein-linked signaling pathways mediate development in Dictyostelium.
G-protein-linked signaling pathways mediate development in Dictyostelium.
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G 蛋白相关信号通路介导盘基网柄菌的发育。
DOI：
10.1101/sqb.1992.057.01.022
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Devreotes,PN
中科院分区：
文献类型：
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作者：
Johnson,RL;Gundersen,R;Hereld,D;Pitt,GS;Tugendreich,S;Saxe,CL;Kimmel,AR;Devreotes,PN
网骨藻是发育研究的一种简单模式生物。在生长条件下，单个变形虫由同质的细胞群组成，但当缺乏营养时，细胞聚集形成由几种不同细胞类型组成的多细胞结构（图1）。当阿米巴原虫迁移到单层内的中心点并形成数千个细胞的聚集体时，首先检测到发育。细胞在聚集体内紧密粘附以形成丘，在丘上形成单个尖端。这种结构上升，福尔斯下降，并形成一个迁移的假原质团或”蛞蝓”，其尖端形成前端。蛞蝓大约一毫米大小，在表面爬行。这个迁移阶段，这可以绕过，是受多种因素，如光，温度和pH值的影响。结果在sorocarp或子实体，其中包括一个死空泡细胞支持一个包裹的孢子质量的柄。孢子暴露于营养物质导致变形虫出现并完成生命周期（Raper 1940; Bonner 1944）。
Dictyostelium is a simple model organism for developmental studies. Under conditions of growth, single amoebae comprise a homogeneous population of cells, but when deprived of nutrients, cells aggregate to form a multicellular structure consisting of several different cell types (Fig. 1). Development is first detected when amoebae migrate to central points within a monolayer and form aggregates of many thousands of cells. Cells become tightly adherent within the aggregate to create a mound, upon which a single tip forms. This structure rises, falls over, and forms a migrating pseudoplasmodium or" slug" with the tip forming the anterior end. Slugs are about a millimeter in size and crawl about the surface. This migratory phase, which can be bypassed, is influenced by multiple factors, such as light, temperature, and pH. Culmination results in a sorocarp or fruiting body, which consists of a stalk of dead vacuolated cells supporting an encased spore mass. Exposure of spores to nutrients causes amoebae to emerge and completes the life cycle (Raper 1940; Bonner 1944).