The logopenic variant of primary progressive aphasia
The logopenic variant of primary progressive aphasia
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DOI：
10.1097/wco.0b013e32833fb93e
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发表时间：
2010-12-01
影响因子：
4.8
通讯作者：
Gorno-Tempini, Maria Luisa
中科院分区：
文献类型：
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作者：
Henry, Maya L.;Gorno-Tempini, Maria Luisa
综述目的旨在探讨原发性进行性失语症的语言减少变异作为一种独特的临床实体的演变，并概述阐明其临床特征、神经基础以及潜在遗传和病理基础的最新进展。当研究人员试图确定原发性进行性失语症亚型的临床病理关系，希望利用语言表型作为潜在疾病的标志物时，这一点尤其重要。最近的研究结果最近的工作有助于完善和扩展语言减少变异的临床表型。语言减少患者表现出一种独特的语言过程幸存和受损的模式，可以可靠地将这种综合征与进行性失语症的其他变体区分开来。具体来说，他们在语义、句法和运动言语能力方面表现出命名和重复方面的缺陷。此外，越来越多的证据表明语言减少表型与特定的病理和遗传相关性之间可能存在联系。研究结果摘要表明，语言减少变异是进行性失语症的一种独特亚型，可能具有作为潜在病理学预测因子的价值。然而，为了进一步阐明认知语言特征并确认其与某些病理和遗传过程的关系，还需要进行更多的研究。
Purpose of reviewThe aim is to explore the evolution of the logopenic variant of primary progressive aphasia as a distinct clinical entity and to outline recent advances that have clarified its clinical characteristics, neural underpinnings, and potential genetic and pathological bases. This is particularly relevant as researchers attempt to identify clinico-pathological relationships in subtypes of primary progressive aphasia in hopes of utilizing language phenotype as a marker of underlying disease.Recent findingsRecent work has served to refine and expand upon the clinical phenotype of the logopenic variant. Logopenic patients show a unique pattern of spared and impaired language processes that reliably distinguish this syndrome from other variants of progressive aphasia. Specifically, they exhibit deficits in naming and repetition in the context of spared semantic, syntactic, and motor speech abilities. Further, there is a growing body of evidence indicating a possible link between the logopenic phenotype and specific pathological and genetic correlates.SummaryFindings indicate that the logopenic variant is a distinct subtype of progressive aphasia that may hold value as a predictor of underlying pathology. Additional research, however, is warranted in order to further clarify the cognitive-linguistic profile and to confirm its relation to certain pathological and genetic processes.