Salt-induced DNA-histone complexation
Salt-induced DNA-histone complexation
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DOI：
10.1103/physrevlett.85.4389
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发表时间：
2000-11-13
影响因子：
8.6
通讯作者：
Netz, RR
中科院分区：
文献类型：
--
作者：
Kunze, KK;Netz, RR
我们对一种半柔性带电聚合物与带相反电荷的球体的结合进行了数值研究。使用适合 DNA-组蛋白复合物的参数，我们发现仅中间盐浓度的完全包裹，与实验一致。对于高盐浓度，会发生强烈不连续的解包裹。对于低盐浓度，我们发现多种构象转变，导致 DNA 构型延伸。包裹态的特点是自发破缺的旋转对称和镜像对称，产生四种不同的结构。
We study numerically the binding of one semiflexible charged polymer onto an oppositely charged sphere. Using parameters appropriate for DNA-histone complexes, we find complete wrapping for intermediate salt concentrations only, in agreement with experiments. For high salt concentrations, a strongly discontinuous dewrapping occurs. For low salt concentrations, we find multiple conformational transitions, leading to an extended DNA configuration. The wrapped states are characterized by spontaneously broken rotational and mirror symmetries, giving rise to four distinct structures.