LncRNA ELF3-AS1 Promotes Nonsmall Cell Lung Cancer Cell Invasion and Migration by Downregulating miR-212
LncRNA ELF3-AS1 Promotes Nonsmall Cell Lung Cancer Cell Invasion and Migration by Downregulating miR-212
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DOI：
10.1089/cbr.2019.3506
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发表时间：
2020-06-27
影响因子：
3.4
通讯作者：
Cheng, Wen-Wu
中科院分区：
文献类型：
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作者：
Zhang, Zhe;Nong, Li;Cheng, Wen-Wu
LncRNA ELF 3-AS 1在膀胱癌和口腔癌中被表征为致癌lncRNA，而其在非小细胞肺癌（NSCLC）中的作用尚不清楚。在这项研究中，作者观察到ELF 3-AS 1在NSCLC组织中的表达与从68名NSCLC患者中收集的配对非肿瘤组织相比上调。ELF 3-AS 1的高表达水平预示着NSCLC患者的生存率低。在NSCLC组织样本中，miR-212的表达水平与ELF 3-AS 1的表达水平呈显著负相关。在NSCLC细胞中，ELF 3-AS 1过表达导致miR-212基因表达下调，甲基化水平升高。此外，ELF 3-AS 1的过表达抑制了miR-212在抑制癌细胞侵袭和迁移中的作用。因此，ELF 3-AS 1在非小细胞肺癌中上调，并通过甲基化下调miR-212来促进癌细胞侵袭和迁移。
LncRNA ELF3-AS1 has been characterized as an oncogenic lncRNA in bladder cancer and oral cancer, whereas its role in nonsmall cell lung cancer (NSCLC) is unknown. In this study, the authors observed that ELF3-AS1 was upregulated in NSCLC tissues in comparison with that in paired nontumor tissues collected from 68 NSCLC patients. High expression levels of ELF3-AS1 predicted the poor survival of NSCLC patients. Expression levels of miR-212 were inversely and significantly correlated with the expression levels of ELF3-AS1 across NSCLC tissue samples. In NSCLC cells, overexpression of ELF3-AS1 led to downregulated miR-212 and increased methylation of miR-212 gene. In addition, overexpression of ELF3-AS1 inhibited the role of miR-212 in suppressing cancer cell invasion and migration. Therefore, ELF3-AS1 is upregulated in NSCLC and promotes cancer cell invasion and migration by downregulating miR-212 through methylation.