Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies.
Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies.
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DOI：
10.1016/j.neurobiolaging.2014.07.005
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发表时间：
2015-01
影响因子：
4.2
通讯作者：
Kantarci K
中科院分区：
文献类型：
--
作者：
Nedelska Z;Ferman TJ;Boeve BF;Przybelski SA;Lesnick TG;Murray ME;Gunter JL;Senjem ML;Vemuri P;Smith GE;Geda YE;Graff-Radford J;Knopman DS;Petersen RC;Parisi JE;Dickson DW;Jack CR Jr;Kantarci K
与阿尔茨海默病痴呆（AD）相比，路易体痴呆（DLB）的特征在于MRI上保留的全脑和内侧颞叶体积。然而，经常共存的AD型病理可能会影响DLB患者的局部脑萎缩率的模式。我们研究了尸检证实的DLB（n=20）和混合DLB/AD患者（n=22）与AD（n=30）和老年非痴呆对照组（n=15）的两个系列MRI萎缩率的模式和幅度，随后进行了死前检查。与对照组相似，无显著AD型病理学的DLB患者的特征为较低的整体和局部萎缩率。混合型DLB/AD患者在全脑、颞顶叶皮质、海马和杏仁核以及脑室扩张中表现出更高的发生率，与AD患者相似。在DLB和DLB/AD患者中，萎缩率与Braak神经元缠结分期、认知功能下降和运动症状进展相关。整体和局部萎缩率与DLB的AD型病理相关，可用作LB病理患者AD进展的生物标志物。
Dementia with Lewy bodies (DLB) is characterized by preserved whole brain and medial temporal lobe volumes compared to Alzheimer’s disease dementia (AD) on MRI. However, frequently coexistent AD-type pathology may influence the pattern of regional brain atrophy rates in DLB patients. We investigated the pattern and magnitude of the atrophy rates from two serial MRIs in autopsy-confirmed DLB (n=20) and mixed DLB/AD patients (n=22), compared to AD (n=30) and elderly non-demented controls (n=15), followed antemortem. DLB patients without significant AD-type pathology were characterized by lower global and regional rates of atrophy, similar to controls. The mixed DLB/AD patients displayed greater rates in the whole brain, temporo-parietal cortices, hippocampus and amygdala, and ventricle expansion, similar to AD patients. In the DLB and DLB/AD patients, the atrophy rates correlated with Braak neurofibrillary tangle stage, cognitive decline and progression of motor symptoms. Global and regional atrophy rates are associated with AD-type pathology in DLB, and can be used as biomarkers of AD progression in patients with LB pathology.
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影响因子：
4.4
作者：
Gunter, JL;Shiung, MM;Jack, CR
通讯作者：
Jack, CR
影响因子：
9.9
作者：
Jack, CR;Shiung, MM;Petersen, RC
通讯作者：
Petersen, RC
影响因子：
4.2
作者：
Ball, M;Braak, H;Khachaturian, Z
通讯作者：
Khachaturian, Z
影响因子：
4.1
作者：
Horvath, Judit;Herrmann, Francois R.;Koevari, Enikoe
通讯作者：
Koevari, Enikoe
影响因子：
14.5
作者：
Graff-Radford, Jonathan;Boeve, Bradley F.;Kantarci, Kejal
通讯作者：
Kantarci, Kejal