The "window of susceptibility" for inflammation in the immature central nervous system is characterized by a leaky blood-brain barrier and the local expression of inflammatory chemokines.
The "window of susceptibility" for inflammation in the immature central nervous system is characterized by a leaky blood-brain barrier and the local expression of inflammatory chemokines.
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DOI：
10.1016/j.nbd.2009.05.026
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发表时间：
2009-09
影响因子：
6.1
通讯作者：
Bradl M
中科院分区：
文献类型：
--
作者：
Schoderboeck L;Adzemovic M;Nicolussi EM;Crupinschi C;Hochmeister S;Fischer MT;Lassmann H;Bradl M
在出生后发育早期，未成熟的中枢神经系统（CNS）比成年的中枢神经系统更容易受到炎症的影响。我们在这里表明，这种“易感性窗口”的特征是中枢神经系统中存在渗漏血管，并且总体趋化因子表达谱与成人中枢神经系统中观察到的表达谱明显不同，并且具有三个重要特征。首先，它含有在神经胶质和神经元的分化和成熟中具有已知作用的趋化因子。其次，这些趋化因子之前已在中枢神经系统炎症病变中被描述过，它们对于单核细胞和 T 细胞的募集很重要。最后，趋化因子谱是由少突胶质细胞应激和髓磷脂修复等病理变化决定的。趋化因子表达谱的变化以及血脑屏障渗漏为中枢神经系统炎症的加速发展奠定了基础。
Early in postnatal development, the immature central nervous system (CNS) is more susceptible to inflammation than its adult counterpart. We show here that this “window of susceptibility” is characterized by the presence of leaky vessels in the CNS, and by a global chemokine expression profile which is clearly distinct from the one observed in the adult CNS and has three important characteristics. First, it contains chemokines with known roles in the differentiation and maturation of glia and neurons. Secondly, these chemokines have been described before in inflammatory lesions of the CNS, where they are important for the recruitment of monocytes and T cells. And last, the chemokine profile is shaped by pathological changes like oligodendrocyte stress and attempts of myelin repair. Changes in the chemokine expression profile along with a leaky blood brain barrier pave the ground for an accelerated development of CNS inflammation.
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作者：
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