Oxidative stress and aging - Role of exercise and its influences on antioxidant systems
Oxidative stress and aging - Role of exercise and its influences on antioxidant systems
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DOI：
10.1111/j.1749-6632.1998.tb09896.x
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发表时间：
1998-01-01
期刊：
影响因子：
--
通讯作者：
Bejma, J
中科院分区：
文献类型：
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作者：
Ji, LL;Leeuwenburgh, C;Bejma, J
剧烈运动的特点是增加耗氧量和干扰细胞内的促氧化剂-抗氧化剂的稳态。至少有三种生化途径，即线粒体电子传递链、黄嘌呤氧化酶和多形中性粒细胞已被确定为运动期间细胞内自由基产生的潜在来源，这些有害的活性氧簇对细胞抗氧化防御系统构成严重威胁，例如抗氧化剂的储备减少维生素和谷胱甘肽，并且已经显示在运动和/或锻炼的肌肉和其它组织中引起氧化损伤。然而，酶和非酶的抗氧化剂已经证明了很大的通用性和适应性，在急性和慢性运动。运动中促氧化剂和抗氧化剂之间的微妙平衡可能会随着年龄的增长而改变。研究在活性氧影响下衰老和运动之间复杂的相互作用，将提供更多的明确信息，老年人应该参与多少体育活动，以及是否需要补充营养抗氧化剂。
Strenuous exercise is characterized by an increased oxygen consumption and disturbance of intracellular prooxidant-antioxidant homeostasis. At least three biochemical pathways, that is, mitochondrial electron transport chain, xanthine oxidase, and polymorphoneutrophil have been identified as potential sources of intracellular free radical generation during exercise, These deleterious reactive oxygen species pose a serious threat to the cellular antioxidant defense system, such as diminished reserve of antioxidant vitamins and glutathione, and have been shown to cause oxidative damage in exercising and/or exercised muscle and other tissues. However, enzymatic and nonenzymatic antioxidants have demonstrated great versatility and adaptability in response to acute and chronic exercise. The delicate balance between prooxidants and antioxidants during exercise may be altered with aging. Study of the complicated interaction between aging and exercise under the influence of reactive oxygen species would provide more definitive information as to how much aged individuals should be involved in physical activity and whether supplementation of nutritional antioxidants would be desirable.