Effects of lamotrigine on cortically-elicited phenomena in adult rats: Differences between acute application and late consequences of early postnatal administration
Effects of lamotrigine on cortically-elicited phenomena in adult rats: Differences between acute application and late consequences of early postnatal administration
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DOI：
10.1016/j.brainres.2008.12.054
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发表时间：
2009-03-03
期刊：
影响因子：
2.9
通讯作者：
Mares, Pavel
中科院分区：
文献类型：
--
作者：
Tsenov, Grygoryi;Redkozubova, Olga;Mares, Pavel
拉莫三嗪（LTG）越来越多地用于儿科癫痫学，但没有实验数据的延迟后果的早期生活管理LTG癫痫现象。因此，我们使用皮质诱导的癫痫现象来研究这些可能的影响，并将结果与成年大鼠急性给药LTG的数据进行比较。未处理的成年大鼠以及在出生后早期具有LTG给药史的动物（从出生后第7天至第11天每天以10和/或20 mg/kg i. p.被植入皮层刺激和记录电极。刺激两组大鼠感觉运动区均诱发大脑半球间反应和癫痫后放电。急性施用LTG（10和/或20 mg/kg i. p.）不影响皮层半球间诱发反应，但增加阈值引起的刺激，尖峰和波AD和伴随的阵挛性发作引起的运动。相反，AD的持续时间增加。出生后注射LTG的动物表现出AD转变为边缘系统类型（混合AD）的阈值增加，边缘系统类型的发生率降低和复发AD的抑制。在早期发育期间接受20 mg/kg剂量LTG的组中，诱发反应表现出更陡峭的输入-输出曲线。我们的研究结果表明，一个特定的抗惊厥作用作为一个延迟的后果，早期生命管理LTG，它不同于急性给药LTG成年大鼠的影响。(C)2008 Elsevier B. V.保留所有权利。
Lamotrigine (LTG) is increasingly used in pediatric epileptology but there are no experimental data on delayed consequences of early life administration of LTG on epileptic phenomena. Therefore we used cortically induced epileptic phenomena to study these possible effects and compared the results with data on acute administration of LTG in adult rats. Naive adult rats as well as animals with a history of LTG administration in early postnatal period (daily from postnatal day 7 to 11 in a dose of 10 and/or 20 mg/kg i.p.) were implanted with cortical stimulation and recording electrodes. Cortical interhemispheric responses and epileptic afterdischarges (ADs) were elicited by stimulation of sensorimotor area in both groups. Acute administration of LTG (10 and/or 20 mg/kg i.p.) did not affect cortical interhemispheric evoked responses but increased thresholds for elicitation of movements elicited by stimulation, spike-and-wave ADs and accompanying clonic seizures. On the contrary, duration of ADs was increased. Animals injected with LTG postnatally exhibited increased thresholds for transition of ADs into a limbic type (mixed ADs), decreased incidence of the limbic type and suppression of recurrent ADs. Evoked responses exhibited a steeper input-output curve in a group receiving the 20 mg/kg dose of LTG during early development. Our results demonstrated a specific anticonvulsant effect as a delayed consequence of early-life administration of LTG; it differed from effects of acute administration of LTG to adult rats. (C) 2008 Elsevier B.V. All rights reserved.