The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis via induction of 15-lipoxygenase-1 in colorectal cancer cells
The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis via induction of 15-lipoxygenase-1 in colorectal cancer cells
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DOI：
10.1158/0008-5472.can-04-1867
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发表时间：
2004-12-01
期刊：
影响因子：
11.2
通讯作者：
Lippman, SM
中科院分区：
文献类型：
--
作者：
Hsi, LC;Xi, XP;Lippman, SM
组蛋白脱乙酰酶； (HDAC) 介导核小体构象的变化，对于基因表达的调节很重要。 HDAC 参与细胞周期进展和分化，其失调与多种癌症相关。 HDAC 抑制剂最近作为有前途的化疗药物出现。其中一种药物辛二酰苯胺异羟肟酸是 HDAC 的有效抑制剂，可在体外和体内引起多种肿瘤类型的生长停滞、分化和/或凋亡。由于其低毒性，辛二酰苯胺异羟肟酸目前正处于治疗癌症的临床试验中。 HDAC 抑制剂诱导表达
Histone deacetylases; (HDACs) mediate changes in nucleosome conformation and are important in the regulation of gene expression. HDACs are involved in cell cycle progression and differentiation, and their deregulation is associated with several cancers. HDAC inhibitors have emerged recently as promising chemotherapeutic agents. One such agent, suberoylanilide hydroxamic, acid, is a potent inhibitor of HDACs that causes growth arrest, differentiation, and/or apoptosis of many tumor types in vitro and in vivo. Because of its low toxicity, suberoylanilide hydroxamic acid is currently in clinical trials for the treatment of cancer. HDAC inhibitors induce the expression of