Glycemic control and the risk for coronary heart disease in patients with non-insulin-dependent diabetes mellitus - The Finnish studies
Glycemic control and the risk for coronary heart disease in patients with non-insulin-dependent diabetes mellitus - The Finnish studies
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DOI：
10.7326/0003-4819-124-1_part_2-199601011-00009
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发表时间：
1996-01-01
影响因子：
39.2
通讯作者：
Laakso, M
中科院分区：
文献类型：
--
作者：
Laakso, M
目的：回顾以人群为基础的研究，调查的关联和性质之间的关联血糖控制和冠心病的风险与非胰岛素依赖型糖尿病（NIDDM）患者。数据来源：研究1包括133例新诊断的NIDDM患者从芬兰东部，谁是45至64岁的基线。这些患者的心血管死亡率随访长达10年。研究2纳入了229例来自芬兰东部的新诊断或既往诊断的NIDDM患者，基线年龄为65 - 74岁。对这些患者进行了长达3.5年的冠心病死亡率和所有冠心病事件的随访研究选择：前瞻性、基于人群的研究，包括血糖控制指标、冠心病和心血管风险评估。结果：研究1：10年心血管疾病死亡率与血糖控制（空腹血糖和糖化血红蛋白A（1）水平）显著线性相关，与治疗方式无关。在独立于其他危险因素的多元Logistic回归分析中，空腹血糖水平高可显著预测心血管死亡率。研究2：糖化血红蛋白A（1c）是与冠心病死亡或所有冠心病事件相关的最重要的单一危险因素。在多元Logistic回归分析中，糖化血红蛋白A（1C）与冠心病死亡显着相关，调整后的其他心血管危险factors.Conclusions：两个前瞻性的，以人口为基础的研究，从芬兰提供证据的线性相关性血糖控制与冠心病的风险在中年和老年NIDDM患者。
Purpose: To review population-based studies that investigated the association and nature of association between glycemic control and the risk for coronary heart disease in patients with non-insulin-dependent diabetes mellitus (NIDDM).Data Sources: Study 1 included 133 newly diagnosed patients with NIDDM from eastern Finland, who were 45 to 64 years of age at baseline. These patients were followed up to 10 years for cardiovascular mortality. Study 2 included 229 newly or previously diagnosed patients with NIDDM from eastern Finland, aged 65 to 74 years at baseline. These patients were followed up to 3.5 years for coronary heart disease mortality and all coronary heart disease events (mortality or nonfatal myocardial infarction).Study Selection: Prospective, population-based studies that included indicators of glycemic control and the evaluation of coronary heart disease and cardiovascular risk.Results: Study 1 : 10-year cardiovascular mortality was significantly and linearly associated with glycemic control (fasting blood glucose and glycated hemoglobin A(1) levels) independently of the mode of treatment. A high fasting blood glucose level significantly predicted cardiovascular mortality in multiple logistic regression analysis independently of other risk factors. Study 2: Glycated hemoglobin A(1c) was the most important single risk factor associated with coronary heart disease death or all coronary heart disease events. In multiple logistic regression analysis, glycated hemoglobin A(1c) was significantly associated with coronary heart disease death after adjustment for other cardiovascular risk factors.Conclusions: Two prospective, population-based studies from Finland give evidence for the linear association of glycemic control with the risk for coronary heart disease in middle-aged and elderly patients with NIDDM.