PATHWAY OF PHOSPHATIDYLINOSITOL(3,4,5)-TRISPHOSPHATE SYNTHESIS IN ACTIVATED NEUTROPHILS
PATHWAY OF PHOSPHATIDYLINOSITOL(3,4,5)-TRISPHOSPHATE SYNTHESIS IN ACTIVATED NEUTROPHILS
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DOI：
10.1038/351033a0
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发表时间：
1991-05-02
期刊：
影响因子：
64.8
通讯作者：
IRVINE, RF
中科院分区：
文献类型：
--
作者：
STEPHENS, LR;HUGHES, KT;IRVINE, RF
由甲酰肽f-Met-LeuPhe激活的中性粒细胞瞬时积累一小部分高极性肌醇脂质。 一个类似的脂质家族也出现在许多其他细胞中，对一系列生长因子和激活的癌基因作出反应，并被推测为3-磷脂酰肌醇激酶的直接或间接产物。 这些脂质的结构被证明是磷脂酰肌醇3-磷酸，磷脂酰肌醇-（3，4）二磷酸和磷脂酰肌醇-（3，4，5）三磷酸，我们目前的证据表明，在完整的中性粒细胞磷脂酰肌醇-（4，5）二磷酸-3-激酶似乎是焦点，通过激动剂刺激形成3-磷酸化肌醇脂质。
Neutrophils activated by the formyl peptide f-Met-LeuPhe transiently accumulate a small subset of highly polar inositol lipids. A similar family of lipids also appear in many other cells in response to a range of growth factors and activated oncogenes, and are presumed to be the direct or indirect products of 3-phosphatidylinositol kinase. The structures of these lipids are shown to be phosphatidylinositol 3-phosphate, phosphatidylinositol-(3,4)bisphosphate and phosphatidylinositol-(3,4,5)trisphosphate, and we present evidence that in intact neutrophils a phosphatidyl-inositol-(4,5)bisphosphate-3-kinase seems to be the focal point through which agonists stimulate the formation of 3-phosphorylated inositol lipids.