Minimum Inhibitory concentration of carbapenems and tigecycline against Salmonella spp.
Minimum Inhibitory concentration of carbapenems and tigecycline against Salmonella spp.
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DOI：
10.1099/jmm.0.47853-0
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发表时间：
2009-03-01
影响因子：
3
通讯作者：
Pillai, Parukutty
中科院分区：
文献类型：
--
作者：
Capoor, Malini R.;Nair, Deepthi;Pillai, Parukutty
沙门氏菌的耐药性分析。令人严重关切的是，在耐喹诺酮类药物和产超广谱β-内酰胺酶(ESBL)的菌株中更是如此，这些菌株会导致复杂的感染。210株沙门氏菌对阿奇霉素、环丙沙星、头孢克新、头孢吡肟、头孢曲松、加替沙星、亚胺培南、左氧氟沙星、美罗培南、氧氟沙星的最低抑菌浓度(E-test试纸)、替吉环素和法罗培南(琼脂稀释法)。已经下定决心。亚胺培南和美罗培南对伤寒沙门氏菌和甲型副伤寒沙门氏菌的MIC90(抑制90%菌株生长的最低抑菌浓度)为0.064微克/毫升。法罗培南对伤寒沙门氏菌、甲型副伤寒沙门氏菌和鼠伤寒沙门氏菌的MIC90为0.25mgml(-1)。阿奇霉素对所有沙门氏菌的MIC90。范围为8~16微克毫升(-1)。替格环素对伤寒沙门氏菌、甲型副伤寒沙门氏菌和鼠伤寒沙门氏菌的MIC90分别为2微克毫升、1微克毫升和4微克毫升。我们得出结论，替吉环素和碳青霉烯类药物可能在治疗耐喹诺酮类和产超广谱β-内酰胺酶的沙门氏菌的最后阶段发挥作用。
Antimicrobial resistance in Salmonella spp. is of grave concern, more so in quinolone-resistant and extended-spectrum beta-lactamase (ESBL)-producing isolates that cause complicated infections. The MIC of azithromycin, ciprofloxacin, cefixime, cefepime, ceftriaxone, gatifloxacin, imipenem, levofloxacin, meropenem and ofloxacin (E-test strip) and tigecycline and faropenem (agar dilution) against 210 Salmonella spp. was determined. MIC90 (defined as the antimicrobial concentration that inhibited growth of 90% of the strains) of the carbapenems (imipenem and meropenem) for Salmonella Typhi and Salmonella Paratyphi A was 0.064 mu g ml(-1). MIC90 of faropenem was 0.25 mu g ml(-1) for S. Typhi, S. Paratyphi A and Salmonella Typhimurium. The MIC90 of azithromycin for all Salmonella spp. ranged from 8 to 16 mu g ml(-1). Tigecycline showed an MIC90 of 2 mu g ml-1 for S. Typhi, 1 mu g ml(-1) for S. Paratyphi A and 4 mu g ml(-1) for S. Typhimurium. We concluded that tigecycline and the carbapenems are likely to have roles in the final stage of treatment of quinolone-resistant and ESBL-producing multidrug-resistant salmonellae.