Short- and Long-Term Effects of Perinatal lnterleukin-1β-Application in Rats
Short- and Long-Term Effects of Perinatal lnterleukin-1β-Application in Rats
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围产期白介素 1β 对大鼠应用的短期和长期影响
DOI：
10.1159/000126560
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发表时间：
1993
影响因子：
4.1
通讯作者：
A. Plagemann
中科院分区：
文献类型：
--
作者：
F. Götz;G. Dörner;U. Malz;W. Rohde;F. Stahl;I. Poppe;M. Schulze;A. Plagemann
神经、内分泌和免疫系统被认为是一个复杂的功能单元，通过其特定的化学信使——神经递质、全身激素和免疫细胞的激素样介质（细胞因子）相互作用。已知细胞因子影响多个内分泌轴。从妊娠第 17 天到第 21 天，每天两次对大鼠进行腹膜内白细胞介素-1β (IL) 给药。一些接受 IL 治疗的母亲在最后一次注射后 1.5 小时被迅速斩首。胎儿是通过剖腹产分娩的。母体血浆 CRF、ACTH 和皮质酮显着升高。胎儿肾上腺和胸腺重量较低，血浆皮质酮与对照组没有差异。男性胎儿血浆睾酮减少，女性雄烯二酮增加。旷场测试显示，IL 后代的总运动活性高于对照组。 IL 后代在斯金纳盒学习中表现出比对照组更差的结果。性行为仅在男性中受到影响，与对照组相比，在去势和雌激素治疗后，女性型脊柱前凸行为的比例更高。 6 个月大时，IL 组对“新环境应激”的反应在血浆皮质酮方面显着低于对照组。这些结果表明，用IL-1β进行产前治疗导致精神运动发育、行为以及神经内分泌系统的长期改变。
Nervous, endocrine and immune systems are regarded as a complex functional unit, interacting by their specific chemical messengers – neurotransmitters, systemic hormones and hormone-like mediators of immune cells (cytokines). Cytokines are known to affect several endocrine axes. Interleukin-lβ (IL) was administered in rats intraperitoneally twice daily from day 17 to 21 of pregnancy. Some of the IL-treated mothers were rapidly decapitated 1.5 h after the last injection. The fetuses were delivered by cesarean section. Maternal plasma CRF, ACTH and corticosterone were found to be significantly elevated. Fetal adrenal and thymus weights were lower, and plasma corticosterone did not differ from controls. Fetal plasma testosterone was decreased in males, androstenedione was increased in females. Open-field testing revealed a higher total locomotor activity of IL offspring than of controls. IL offspring showed worse results in Skinner box learning than controls. Sexual behavior was only affected in males, showing a higher percentage of female-type lordosis behavior after castration and estrogen treatment compared to controls. At the age of 6 months responsiveness to ‘novel-environment stress’ of IL groups was significantly lower than that of controls in terms of plasma corticosterone. These results indicate that prenatal treatment with IL-lβ results in long-lasting alterations in psychomotor development, behavior as well as in the neuroendocrine system.