DESIGN AND INVITRO STUDIES OF A NEEDLE-TYPE GLUCOSE SENSOR FOR SUBCUTANEOUS MONITORING
DESIGN AND INVITRO STUDIES OF A NEEDLE-TYPE GLUCOSE SENSOR FOR SUBCUTANEOUS MONITORING
复制标题
DOI：
10.1021/ac00017a008
复制
发表时间：
1991-09-01
影响因子：
7.4
通讯作者：
REACH, G
中科院分区：
文献类型：
--
作者：
BINDRA, DS;ZHANG, YN;REACH, G
研制了一种用于皮下血糖监测的新型小型化葡萄糖氧化物型针状葡萄糖微传感器。该传感器在形状和大小上相当于一根26英寸的针(0.45毫米直径)。且无需任何切开即可轻松植入。这种新的结构极大地促进了酶和聚合物薄膜的沉积，因此能够以较高的产率(60%)制备出适合体内使用的传感器(线性范围上限为15 mm，响应时间为5分钟，在正常基础葡萄糖水平下的灵敏度为5：1的信号与背景比)。传感器的响应在很大程度上独立于正常生理范围内的氧分压。除了外源性药物对乙酰氨基酚外，它对常见干扰也表现出良好的选择性。
A new miniaturized glucose oxidase based needle-type glucose microsensor has been developed for subcutaneous glucose monitoring. The sensor is equivalent in shape and size to a 26-gauge needle (0.45-mm o.d.) and can be implanted with ease without any incision. The novel configuration greatly facilitates the deposition of enzyme and polymer films so that sensors with characteristics suitable for in vivo use (upper limit of linear range > 15 mM, response time < 5 min, and sensitivity yielding a 5:1 signal-to-background ratio at normal basal glucose levels) can be prepared in high yield (> 60%). The sensor response is largely independent of oxygen tension in the normal physiological range. It also exhibits good selectivity against common interferences except for the exogenous drug acetaminophen.