Lactation in the Human Breast From a Fluid Dynamics Point of View
Lactation in the Human Breast From a Fluid Dynamics Point of View
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从流体动力学的角度看人类乳房的哺乳
DOI：
10.1115/1.4034995
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Hassanipour, Fatemeh
中科院分区：
文献类型：
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作者：
Negin Mortazavi, S.;Geddes, Donna;Hassanipour, Fatemeh
这项研究是哺乳专家和流体动力学工程师共同努力的结果。本文介绍了哺乳人类乳房的哺乳压力模式的临床结果，以及利用这些临床输入的三维计算流体动力学（CFD）奶流模型。研究开始时，对一组婴儿的吸吮真空压力、奶流率和奶摄入量进行了仔细的、具有统计学代表性的测量。临床资料表明，婴儿的哺乳动作不是以恒定的哺乳速度发生的，而是有节奏的变化。这些压力分布然后被用作CFD研究的边界条件，使用商业ansys fluent软件。对于人类乳房导管系统的几何模型，这项工作利用了最近在开发已被验证的幻影方面取得的进展，该幻影已被作为乳房成像应用的基础事实。在上述边界条件下，将几何模型引入CFD模拟。将CFD模拟结果与临床数据进行了比较和交叉验证。此外，还介绍和分析了母乳摄取量随哺乳压力的变化。临床和CFD模拟均表明，最大奶流量与最大真空压力和最长喂养时间无关，表明还有其他因素影响婴儿的吸奶量。
This study is a collaborative effort among lactation specialists and fluid dynamic engineers. The paper presents clinical results for suckling pressure pattern in lactating human breast as well as a 3D computational fluid dynamics (CFD) modeling of milk flow using these clinical inputs. The investigation starts with a careful, statistically representative measurement of suckling vacuum pressure, milk flow rate, and milk intake in a group of infants. The results from clinical data show that suckling action does not occur with constant suckling rate but changes in a rhythmic manner for infants. These pressure profiles are then used as the boundary condition for the CFD study using commercialansys fluentsoftware. For the geometric model of the ductal system of the human breast, this work takes advantage of a recent advance in the development of a validated phantom that has been produced as a ground truth for the imaging applications for the breast. The geometric model is introduced into CFD simulations with the aforementioned boundary conditions. The results for milk intake from the CFD simulation and clinical data were compared and cross validated. Also, the variation of milk intake versus suckling pressure are presented and analyzed. Both the clinical and CFD simulation show that the maximum milk flow rate is not related to the largest vacuum pressure or longest feeding duration indicating other factors influence the milk intake by infants.