Influence of aerosol injection on the liquid chemistry induced by an RF argon plasma jet
Influence of aerosol injection on the liquid chemistry induced by an RF argon plasma jet
复制标题
气溶胶注射对射频氩等离子体射流引起的液体化学的影响
DOI：
--
复制
发表时间：
2021
影响因子：
3.8
通讯作者：
K. Wende
中科院分区：
文献类型：
--
作者：
Ivana Sremački;G. Bruno;H. Jablonowski;C. Leys;A. Nikiforov;K. Wende
提出了一种环形结构的射频驱动等离子体射流，并将气溶胶注入到流出物中，用于等离子体医学领域中可控的活性氧(ROS)/活性氮(RNS)的产生和在生物靶标上的传递，例如伤口护理。结合物理和化学分析，研究了水气溶胶在调节活性物种产生中的作用。应用了光学发射光谱、电子顺磁共振光谱和以半胱氨酸为示踪分子的生物化学模型，揭示了气溶胶的注入将ROS的产生从原子氧和单线态氧转移到了液滴中产生的羟基自由基。物种的生成主要发生在液滴通过流出物的传输过程中的边界层，导致引入气溶胶溶液后半胱氨酸的周转有限。随后未修饰的半胱氨酸分子在靶点上的输送表明了血浆源在局部给药中的应用，扩大了潜在的适用性和有效性。RNS的存在是可以忽略不计的气溶胶注射，只有微量的下游产品硝酸盐和硝酸盐被检测到。总而言之，向流出物中注入气雾剂开辟了控制紫外线辐射和非热等离子体源生物医学应用的活性物种输出的新途径，向靶向应用的调节、安全性和有效性延伸。
A radio-frequency driven plasma jet in annular geometry coupled with an aerosol injection into the effluent is proposed for the controllable reactive oxygen species (ROS)/reactive nitrogen species (RNS) production and delivery on biological targets in the context of plasma medicine, e.g. wound care. The role of the aqueous aerosol in modulating the reactive species production is investigated by combining physical and chemical analytics. Optical emission spectroscopy, electron paramagnetic resonance spectroscopy, and a biochemical model based on cysteine as a tracer molecule have been applied, revealing that aerosol injection shifts the production of ROS from atomic and singlet oxygen toward hydroxyl radicals, which are generated in the droplets. Species generation occurred mainly at the droplets boundary layer during their transport through the effluent, leading to a limited cysteine turnover upon introduction into the aerosol solution. The subsequent delivery of unmodified cysteine molecules at a target suggested the application of the plasma source for the topical delivery of drugs, expanding the potential applicability and effectiveness. The presence of RNS was negligible regardless of aerosol injection and only traces of the downstream products nitrate and nitrate were detected. In summary, the aerosol injection into the effluent opens new avenues to control UV radiation and reactive species output for the biomedical applications of non-thermal plasma sources, reaching out toward the regulation, safety, and efficacy of targeted applications.
影响因子：
3.8
作者：
Hendawy, N.;McQuaid, H.;Maguire, P.
通讯作者：
Maguire, P.
影响因子：
6.3
作者：
Haijie Tong;Andrea M. Arangio;P. Lakey;T. Berkemeier;Fobang Liu;C. Kampf;W. Brune;U. Pöschl;M. Shiraiwa
通讯作者：
Haijie Tong;Andrea M. Arangio;P. Lakey;T. Berkemeier;Fobang Liu;C. Kampf;W. Brune;U. Pöschl;M. Shiraiwa