A systematic review on the effects of the chlorhexidine chip when used as an adjunct to scaling and root planing in the treatment of chronic periodontitis
A systematic review on the effects of the chlorhexidine chip when used as an adjunct to scaling and root planing in the treatment of chronic periodontitis
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DOI：
10.1902/jop.2006.050216
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发表时间：
2006-02-01
影响因子：
4.3
通讯作者：
Wyn, Iris
中科院分区：
文献类型：
--
作者：
Cosyn, Jan;Wyn, Iris
背景：一些局部抗菌药物，如生物可吸收的氯己定芯片，已经被开发出来，以提高非手术牙周治疗的效果。方法：通过电子检索（MEDLINE和Cochrane口腔健康组专业试验注册）和人工检索来检测有关使用氯己定芯片作为刮治和牙根规划辅助治疗慢性牙周炎的研究。仅纳入2005年6月前发表的英文随机对照试验全文。结果：经两位审稿人独立筛选，最终入选5项研究。由于研究设计存在相当大的异质性，因此进行了定性数据分析。多中心研究表明，与单纯刮治和牙根刨平相比，机械清创联合反复使用氯己定芯片可显著提高牙袋缩小率和临床附着度。然而，最近的一些研究未能证实氯己定芯片的附加价值。在方法学质量和研究设计方面的一些研究间差异可能是导致这种缺乏一致性的原因。结论：目前有关氯己定芯片的临床和微生物学数据有限且相互矛盾。需要更多的研究来阐明氯己定芯片作为洗牙和刨根辅助工具的附加价值。
Background: Several local antimicrobial agents, such as a bioabsorbable chlorhexidine chip, have been developed to enhance the outcome of non-surgical periodontal therapy.Methods: Electronic (MEDLINE and Cochrane Oral Health Group Specialized Trials Register) and manual searches were performed to detect studies concerning the use of the chlorhexidine chip as an adjunct to scaling and root planing in the treatment of chronic periodontitis. Only full-text randomized controlled trials published in English up to June 2005 were included.Results: Five studies were finally selected following independent screening by two reviewers. Due to considerable heterogeneity in study design, a qualitative data analysis was performed. Multicenter studies have indicated significantly higher pocket reductions and clinical attachment gains following a combination of mechanical debridement and repeated chlorhexidine chip administration in comparison to scaling and root planing alone. However, some recent studies failed to confirm the additional value of the chlorhexidine chip. A number of interstudy disparities with respect to methodological quality and study design may account for this lack of accordance.Conclusions: The clinical and microbiological data currently available on the chlorhexidine chip are limited and conflicting. More research is needed to elucidate the additional value of the chlorhexidine chip when used as an adjunct to scaling and root planing.