[The 5-HT2B receptor: a main cardio-pulmonary target of serotonin].
[The 5-HT2B receptor: a main cardio-pulmonary target of serotonin].
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发表时间：
2004
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通讯作者：
N. Etienne;B. Schaerlinger;F. Jaffré;L. Maroteaux
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作者：
N. Etienne;B. Schaerlinger;F. Jaffré;L. Maroteaux
与文献中先前的数据一致，我们的研究结果表明，血清素，一种单胺神经递质，也可以调节细胞增殖，细胞运动和细胞分化。我们最近发现，血清素是胚胎心脏发育所必需的。5-HT 2B受体的基因切除导致部分胚胎和出生后死亡，心脏发育异常。类似的分子机制似乎涉及成年心肌细胞，因为存活至成年的突变小鼠显示扩张型心肌病。此外，该受体似乎参与心肌细胞的存活。5-HT 2B受体也与全身性高血压有关。此外，5-HT 2B受体的药理学或基因消融的小鼠对缺氧诱导的肺动脉高压完全耐受，表明该受体调节导致这种疾病的病理性血管增殖。潜在的机制仍有待发现。
In agreement with previous data in the literature, our results indicate that serotonin, a monoamine neurotransmitter, can also regulate cell proliferation, cell movements and cell differentiation. We have recently shown that serotonin is required for embryonic heart development. Genetic ablation of the 5-HT2B receptor leads to partial embryonic and postnatal lethality with abnormal heart development. Similar molecular mechanisms seem to be involved in adult cardiomyocytes since mutant mice surviving to adulthood display a dilated cardiomyopathy. Furthermore this receptor appears to be involved in survival of cardiomyocytes. The 5-HT2B receptor is also implicated in systemic hypertension. Furthermore, mice with pharmacological or genetic ablation of 5-HT2B receptor are totally resistant to hypoxia-induced pulmonary hypertension, indicating that this receptor is regulating the pathologic vascular proliferation leading to this disease. Underlying mechanisms are still to be discovered.