Interleukin-33 Triggers B1 Cell Expansion and Its Release of Monocyte/Macrophage Chemoattractants and Growth Factors
Interleukin-33 Triggers B1 Cell Expansion and Its Release of Monocyte/Macrophage Chemoattractants and Growth Factors
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DOI：
10.1111/sji.12312
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发表时间：
2015-08-01
影响因子：
3.7
通讯作者：
Koma, Mousa Komai
中科院分区：
文献类型：
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作者：
Ahmed, Ammad;Koma, Mousa Komai
B1 B淋巴细胞是主要在腹膜和粘膜部位发现的天然IgM产生细胞。它们在抵抗病毒和细菌感染的早期防御中发挥重要作用。小鼠B1细胞在活化时表达IL-33受体复合物。IL-33是IL-1家族的新成员，在Th 2免疫中具有很强的作用。已经认识到B1细胞通过响应白细胞介素-33产生IgM和IL-5而加剧接触敏感性。然而，IL-33/ST 2信号转导在B1细胞中的确切反应尚未完全了解。在这项研究中，我们报告说，小鼠B1细胞直接响应IL-33在ST 2依赖的方式。这种相互作用在体内以时间依赖性方式刺激B1 b细胞增殖。此外，它还通过B1细胞释放趋化因子（MCP-1和MIP-1 α）介导单核细胞/巨噬细胞和粒细胞募集。值得注意的是，刺激后，B1 b细胞还释放血管生成诱导剂血管内皮生长因子和粒细胞-单核细胞集落刺激因子（GM-CSF）。我们的研究结果表明，这些IL-33介导的B1细胞可能能够在单核细胞和粒细胞的募集和生长中发挥重要作用。
B1 B lymphocytes are natural IgM-producing cells primarily found in peritoneum and mucosal sites. They perform vital functions during the early defence against viral and bacterial infections. Murine B1 cells express IL-33 receptor complex on activation. IL-33 is a new addition to the IL-1 family with a strong role in Th2 immunity. B1 cells have been recognized to exacerbate contact sensitivity by producing IgM and IL-5 in response to interleukin-33. However, the exact response of IL-33/ST2 signalling in B1 cells is not completely understood. In this study, we report that murine B1 cells respond directly to IL-33 in a ST2-dependent manner. This interaction instigates B1b cell proliferation in a time-dependent manner invivo. Furthermore, it also mediates monocyte/macrophage and granulocyte recruitment via B1 cell release of chemokines (MCP-1 and MIP-1 alpha). It was noted that upon stimulation, B1b cells additionally release an angiogenic inducer vascular endothelial growth factor and granulocyte-monocyte colony-stimulating factor (GM-CSF). Our findings suggest that these IL-33-mediated B1 cells might be able to play a vital role in the recruitment and growth of monocytes and granulocytes.