Ischemic Stroke Subtypes in a Japanese Population Takashima Stroke Registry, 1988-2004
Ischemic Stroke Subtypes in a Japanese Population Takashima Stroke Registry, 1988-2004
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DOI：
10.1161/strokeaha.110.581033
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发表时间：
2010-09-01
期刊：
影响因子：
8.3
通讯作者：
Ueshima, Hirotsugu
中科院分区：
文献类型：
--
作者：
Turin, Tanvir Chowdhury;Kita, Yoshikuni;Ueshima, Hirotsugu
背景和目的-基于人群的缺血性卒中（IS）亚型的流行病学信息很少。在这项研究中，我们的特点是亚型的发病率，时间趋势，和危险因素配置文件在以社区为基础的population. Methods，我们从高岛中风登记处获得的数据约55 000名居民的高岛县在日本中部和计算年龄调整后的中风发病率为不同的IS亚型。我们确定的发病率的时间趋势，通过计算跨年的平均年变化，也比较了亚型之间的危险因素。结果，有1389首次缺血性中风登记在1988年至2004年。腔隙性梗死是最常见的病因（54.1%），其次是心源性梗死（22.9%）。不同IS亚型的经胃镜校正的发病率为腔隙性，77.1;心源性，31.5;非腔隙性，29.7/10（5）人-年。除非腔隙性脑梗死呈下降趋势外，IS亚型的平均年变化无显著性。危险因素分析表明，腔隙性脑梗死患者更年轻，不太可能有短暂性脑缺血发作或饮酒的习惯比nonlacunar infarcts. Conclusion腔隙性脑梗死的患者是最常见的IS亚型在我们的人口。我们发现在研究过程中，除了非腔隙性脑梗死的发生率下降外，其他亚型的发生率没有显著变化。（中风。2010; 41：1871-1876.）
Background and Purpose-Population-based information on the epidemiology of ischemic stroke (IS) subtypes is scant. In this study, we characterized IS subtypes in terms of incidence, time trend, and risk factor profiles in a community-based population.Methods-We obtained data from the Takashima Stroke Registry on approximately 55 000 residents of Takashima County in central Japan and calculated age-adjusted stroke incidence rates for different IS subtypes. We determined the incidence time trend by calculating the average annual change across years and also compared risk factors between subtypes.Results-There were 1389 first-ever ischemic strokes registered during 1988 to 2004. Lacunar infarction was the most frequent etiology (54.1%) followed by cardioembolic infarction (22.9%). Age-adjusted incidence rates for different IS subtypes were lacunar, 77.1; cardioembolic, 31.5; and nonlacunar, 29.7/10(5) person-years. The average annual change was not significant for the IS subtypes except for nonlacunar infarction, which showed a decreasing trend. Risk factor analysis showed that patients with lacunar infarctions were younger and less likely to have a history of transient ischemic attack or a drinking habit than patients with nonlacunar infarctions.Conclusion-Lacunar infarct was the most common IS subtype in our population. We found no significant change in the incidence of subtypes during the study, except a decrease in nonlacunar infarction. (Stroke. 2010; 41:1871-1876.)