Toward a three-dimensional view of protein networks between species.
Toward a three-dimensional view of protein networks between species.
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DOI：
10.3389/fmicb.2012.00428
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发表时间：
2012
影响因子：
5.2
通讯作者：
Xia Y
中科院分区：
文献类型：
--
作者：
Franzosa EA;Garamszegi S;Xia Y
物种间生物分子相互作用的一般原理与物种内相互作用的已知原理有很大不同，但这些原理在系统水平上仍然知之甚少。这种知识差距的一个关键原因是缺乏物种之间生物分子相互作用网络的详细三维（3D）原子视图。结构生物学、系统生物学和计算生物学的最新进展使得能够精确和大规模地构建物种内和物种之间蛋白质-蛋白质相互作用网络的节点和边缘的3D结构模型。由此产生的物种内和物种间的结构相互作用网络提供了新的生物物理，功能和进化的物种相互作用和传染病的见解。在这里，我们回顾了物种间结构系统生物学的新生领域，重点是宿主和病原体（如病毒）之间的相互作用。
General principles governing biomolecular interactions between species are expected to differ significantly from known principles governing the interactions within species, yet these principles remain poorly understood at the systems level. A key reason for this knowledge gap is the lack of a detailed three-dimensional (3D), atomistic view of biomolecular interaction networks between species. Recent progress in structural biology, systems biology, and computational biology has enabled accurate and large-scale construction of 3D structural models of nodes and edges for protein–protein interaction networks within and between species. The resulting within- and between-species structural interaction networks have provided new biophysical, functional, and evolutionary insights into species interactions and infectious disease. Here, we review the nascent field of between-species structural systems biology, focusing on interactions between host and pathogens such as viruses.
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影响因子：
3.7
作者：
Dyer MD;Neff C;Dufford M;Rivera CG;Shattuck D;Bassaganya-Riera J;Murali TM;Sobral BW
通讯作者：
Sobral BW
DOI：
10.1016/s1574-1400(08)00001-7
发表时间：
2010-01-01
期刊：
ANNUAL REPORTS IN COMPUTATIONAL CHEMISTRY, VOL 4
影响因子：
--
作者：
Franzosa, Eric;Xia, Yu
通讯作者：
Xia, Yu
影响因子：
14.9
作者：
Driscoll T;Dyer MD;Murali TM;Sobral BW
通讯作者：
Sobral BW
影响因子：
14.9
作者：
Gould CM;Diella F;Via A;Puntervoll P;Gemünd C;Chabanis-Davidson S;Michael S;Sayadi A;Bryne JC;Chica C;Seiler M;Davey NE;Haslam N;Weatheritt RJ;Budd A;Hughes T;Pas J;Rychlewski L;Travé G;Aasland R;Helmer-Citterich M;Linding R;Gibson TJ
通讯作者：
Gibson TJ
影响因子：
8
作者：
Davis, Fred P.;Barkan, David T.;Sali, Andrej
通讯作者：
Sali, Andrej