A novel thermal treatment modality for controlling breast tumor growth and progression
A novel thermal treatment modality for controlling breast tumor growth and progression
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DOI：
10.1109/embc.2012.6347290
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发表时间：
2012-11
期刊：
影响因子：
--
通讯作者：
Yifan Xie;Ping Liu;L. Xu
中科院分区：
文献类型：
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作者：
Yifan Xie;Ping Liu;L. Xu
原位控制原发肿瘤以抑制远处病灶的新概念为转移性肿瘤的新治疗提供了新的思路。热疗被认为是控制肿瘤生长的手段之一。在这项研究中，建立了一种新的热模式，引入热效应对肿瘤的抑制其生长和发展，使用4T1小鼠乳腺癌，一种常见的转移性乳腺癌动物模型。使用热加热垫对植入肿瘤的皮肤表面施加适度升高的温度（即39 °C）。周期性加热（每天12小时）分别进行3天、7天、14天和21天。发现肿瘤生长速率与没有热疗的对照相比显著降低。通过组织学分析研究了与肿瘤血管生成和转移相关的生物学证据。因此，还研究了轻度高温对免疫细胞浸润到肿瘤中的影响。研究表明，通过介导肿瘤细胞凋亡、血管损伤、降低转移潜能以及抑制免疫抑制细胞髓源性抑制细胞（MDSC）募集来实现延迟肿瘤生长和恶性进展。在不久的将来，将进行进一步的机制研究，以探索肿瘤进展和热剂量之间的定量关系。
The new concept of keeping primary tumor under control in situ to suppress distant foci sheds light on the novel treatment of metastatic tumor. Hyperthermia is considered as one of the means for controlling tumor growth. In this study, a novel thermal modality was built to introduce hyperthermia effect on tumor to suppress its growth and progression using 4T1 murine mammary carcinoma, a common animal model of metastatic breast cancer. A mildly raised temperature (i.e.39°C) was imposed on the skin surface of the implanted tumor using a thermal heating pad. Periodic heating (12 hours per day) was carried out for 3 days, 7 days, 14 days, and 21 days, respectively. The tumor growth rate was found significantly decreased in comparison to the control without hyperthermia. Biological evidences associated with tumor angiogenesis and metastasis were examined using histological analyses. Accordingly, the effect of mild hyperthermia on immune cell infiltration into tumors was also investigated. It was demonstrated that a delayed tumor growth and malignancy progression was achieved by mediating tumor cell apoptosis, vascular injury, degrading metastasis potential and as well as inhibiting the immunosuppressive cell myeloid derived suppressor cells (MDSCs) recruitment. Further mechanistic studies will be performed to explore the quantitative relationship between tumor progression and thermal dose in the near future.