Hemangiopericytoma-like intranasal tumors. A clinicopathologic study of 23 cases.
Hemangiopericytoma-like intranasal tumors. A clinicopathologic study of 23 cases.
复制标题
血管外皮细胞瘤样鼻内肿瘤。
DOI：
10.1093/ajcp/66.4.672
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发表时间：
1976
影响因子：
3.5
通讯作者：
V. Hyams
中科院分区：
文献类型：
--
作者：
J. Compagno;V. Hyams
对23例鼻内血管外皮细胞瘤样肿瘤的临床、镜下和大体病理特征进行回顾和研究。当发生在鼻腔时，这些病变常起源于鼻旁窦，继而延伸至鼻腔。它们最常见于六七十岁的成年人；没有显着的性别偏好。 23 名患者中有 22 名是白人。这些患者最常见的症状是鼻塞和鼻出血。临床上通常认为病变代表过敏性息肉。尽管在显微镜下表现为未分化的梭形细胞肿瘤，但这些病变几乎没有表现出核或细胞质的多形性，有丝分裂活性极低，并且没有恶性肿瘤中发现的坏死或出血或其他变形的证据。后续数据显示没有证据表明存在恶性或生物学上不可预测的病变。随访的 22 例患者中，有 19 例无论采取何种治疗均未出现复发；那些复发的病例是在当地发生的。在该系列中没有发现其他解剖位置的血管外皮细胞瘤引起的转移或其他形式的侵袭行为。另一例被诊断为鼻腔恶性血管外皮细胞瘤，表现出不同的和间变性的组织学特征。该病例已转移并进行了讨论，但未包括在本研究中。
The clinical, microscopic, and gross pathologic features of 23 cases of intranasal hemangiopericytoma-like tumors are reviewed and studied. When in the nasal cavity, these lesions often originated in a paranasal sinus and extended into the nasal cavity secondarily. They occurred most commonly in adults in the sixth and seventh decades of life; there was no significant sex predilection. Twenty-two of the 23 patients were Caucasian. These patients most commonly had symptoms of nasal obstruction and epistaxis. Clinically the lesions were generally thought to represent allergic polyps. Although appearing microscopically as non-differentiated spindle-cell neoplasms, these lesions showed little nuclear or cytoplasmic pleomorphism, minimal mitotic activity, and no necrosis or hemorrhage or other evidence of anaplasia found in malignant tumors. Follow-up data showed no evidence to suggest a malignant or biologically unpredictable lesion. Nineteen of 22 cases followed showed no recurrence regardless of the treatment; those that recurred did so locally. No metastasis or other form of aggressive behavior attributed to hemangiopericytomas in other anatomic locations was seen in this series. Another case, diagnosed as a malignant hemangiopericytoma of the nasal cavity, showed dissimilar and anaplastic histologic features. This case metastasized and is discussed, though not included in this study.