Urinary NMP22 and renal cell carcinoma
Urinary NMP22 and renal cell carcinoma
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DOI：
10.1016/s0090-4295(99)00401-x
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发表时间：
2000-02-01
期刊：
影响因子：
2.1
通讯作者：
Kaswick, J
中科院分区：
文献类型：
--
作者：
Huang, S;Rhee, E;Kaswick, J
目标。证明尿核基质蛋白 22 (NMP22) 值阳性的发生率与肾脏肾细胞癌 (RCC) 相关。目前，尿液NMP22用于检测复发性膀胱移行细胞癌。方法。从1997年5月到1998年3月，从65名接受腹部计算机断层扫描或肾脏超声检查的患者中获得了尿液NMP22值。在这 65 名患者中，有 32 名患者出现肾脏实性肿块。这些患者接受了根治性或部分肾切除术；随后的病理检查显示，其中50人患有肾细胞癌。两名患者患有嗜酸细胞瘤。其余 33 名患者因腹部钝性外伤或腹痛或因泌尿系统问题（肾结石或良性肾囊肿）而接受随访。这些患者在影像学上没有肾恶性肿瘤的证据，并用作对照。结果。 RCC 患者尿 NMP22 值显着高于对照组（13.69 +/- 8.40 U/mL vs 3.03 +/- 2.70 U/mL，P
Objectives. To demonstrate the incidence of positive urinary nuclear matrix protein 22 (NMP22) values associated with renal cell carcinoma (RCC) of the kidney. Currently, urinary NMP22 is used to detect recurrent transitional cell carcinoma of the bladder.Methods. From May 1997 to March 1998, urinary NMP22 values were obtained from 65 patients who had undergone either computed tomography scanning of the abdomen or renal ultrasound. Of the 65, 32 presented with solid renal masses. These patients underwent radical or partial nephrectomy; subsequent pathologic examination revealed that 50 had RCC. Two patients had oncocytomas. The remaining 33 patients presented with blunt abdominal trauma or abdominal pain or for follow-up for a urologic problem (a kidney stone or benign renal cyst). These patients had no evidence of renal malignancy on imaging and were used as controls.Results. The urinary NMP22 values of patients with RCC were significantly higher than the values found in the control group (13.69 +/- 8.40 U/mL versus 3.03 +/- 2.70 U/mL, P