High lifetime incidence of adult acute lymphoblastic leukemia among Hispanics in California.
High lifetime incidence of adult acute lymphoblastic leukemia among Hispanics in California.
复制标题
加利福尼亚州西班牙裔在成年急性淋巴细胞白血病的终生发病率很高。
DOI：
10.1158/1055-9965.epi-07-2949
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发表时间：
2009-02
期刊：
影响因子：
--
通讯作者：
Cozen W
中科院分区：
文献类型：
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作者：
Pullarkat ST;Danley K;Bernstein L;Brynes RK;Cozen W
众所周知，西班牙裔儿童的急性淋巴细胞白血病 (ALL) 发病率高于其他种族/族裔群体。我们评估了成人 ALL 的发病模式。我们使用加州癌症登记处的数据分析了加州 1988 年至 2004 年诊断的所有患者中 ALL 的发病率（ICD-03 代码 9835-9837），以确定与非西班牙裔白人（白人）相比，成年西班牙裔是否也有更高的 ALL 发病率。使用 SEER*Stat 获得年龄调整发病率 (AAIR)、发病率比 (IRR) 和 5 年生存率。其他白血病亚型的 AAIR 和相对于非西班牙裔白人的 IRR 也作为 ALL 的参考进行了检查。 20-54 岁西班牙裔男性和女性 ALL 的 AAIR 高于白人男性和女性（分别为 IRR=1.99，95% CI=1.74-2.28 和 IRR=1.91，95% CI=1.60-2.25）。在老年（55 岁以上）西班牙裔女性中也观察到 ALL 的 AAIR 较高（IRR=1.84，95% CI=1.52–2.21），但男性则不然（IRR= 1.07，95% CI= 0.84–1.34）。在西班牙裔中，与高/中 SES 相比，低社会经济地位 (SES) 与较高的 AAIR 相关（IRR= 1.33，95% CI=1.04–1.70）。 20-54 岁的白人和西班牙裔 ALL 患者的五年生存率分别为 38% 和 30%，55 岁或以上的患者的五年生存率为 8% 和 12%。与其他种族/族裔群体相比，西班牙裔其他主要白血病亚型的 IRR 并未增加。西班牙裔人一生中 ALL 的发病率较高，但其他亚型则不然。
The higher incidence of acute lymphoblastic leukemia (ALL) among Hispanic children relative to that in other racial/ethnic groups is well-known. We evaluated incidence patterns of ALL in adults. We analyzed the incidence patterns of ALL (ICD-03 codes 9835–9837) among all patients diagnosed from 1988–2004 in California using data from the California Cancer Registry to determine whether adult Hispanics also had higher incidence rates of ALL compared to non-Hispanic Whites (Whites). Age-adjusted incidence rates (AAIR), incidence rate ratios (IRR) and 5-year survival rates were obtained using SEER*Stat. AAIRs of other leukemia subtypes and IRRs relative to non-Hispanic whites were also examined as references of ALL. AAIRs of ALL in Hispanic males and females ages 20–54 years were higher compared to those in White males and females (IRR=1.99,95% CI=1.74–2.28 and IRR=1.91,95% CI=1.60–2.25 respectively). A higher AAIR of ALL was also observed among older (55+ years) Hispanic females (IRR=1.84, 95% CI=1.52–2.21), but not males (IRR= 1.07, 95% CI= 0.84–1.34). Among Hispanics, low socioeconomic status (SES) was associated with a higher AAIR compared to high/middle SES (IRR= 1.33, 95% CI=1.04–1.70). The respective five-year survival rates among ALL patients were 38% and 30% for Whites and Hispanics ages 20–54 years, and 8% and 12% for patients 55 years of age or older. Compared to other racial/ethnic groups, Hispanics did not have an increased IRR of the other major leukemia subtypes. Hispanics experience a higher incidence of ALL throughout life, but not other subtypes.