Intracellular pH, intrauterine growth and the insulin resistance syndrome.
Intracellular pH, intrauterine growth and the insulin resistance syndrome.
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细胞内 pH 值、子宫内生长和胰岛素抵抗综合征。
DOI：
10.1046/j.1365-2281.2001.00340.x
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
J. Yudkin
中科院分区：
文献类型：
--
作者：
J. Pinkney;P. Vernon;E. Carstensen;S. Gillies;D. Phillips;J. Yudkin
在冠心病 (CHD) 风险增加的受试者中，钠氢交换 (NHE) 和钠锂逆向转运 (SLC) 均存在缺陷。钠转运与细胞体积、细胞内 pH 值和细胞生长的调节有关，这可以解释这种关联的各个方面。然而，生命早期的生长受损也与成年冠心病有关，细胞行为的“程序化”改变被认为是造成这种情况的原因。因此，在这项研究中，我们研究了成人 NHE 或 SLC 是否可以通过出生时的人体测量来预测，以及是否与成年期的胰岛素抵抗综合征 (IRS) 变量相关。对 26 名成人的红细胞 SLC 进行了测量，并对另外 15 名受试者的真皮成纤维细胞进行了 NHE 测量，这些受试者在出生时进行了人体测量。 SLC 活性与 LDL 胆固醇、甘油三酯和尿酸盐相关（r=0.42 - 0.49；0.05 > P>0.01），但与出生人体测量无关。 NHE V(max) 与血浆胰岛素相关（r=0.80；P<0.001），但出生体重与 V(max)、K(m) 或 H(i)(+) 的 Hill 系数无关。然而，pH(i)与出生体重（r=0.74；P=0.002）、胰岛素敏感性（r=0.52；P<0.05）、空腹血糖（r=-0.52；P<0.05）2小时胰岛素（r=0.51；P<0.05）2小时血糖（r=-0.54；P<0.05）相关。总之，红细胞 SLC 与 IRS 变量相关，但与出生体重测量无关。相比之下，低细胞内 pH(i) 与低出生体重和成人胰岛素抵抗相关，表明它可能是一种“程序化”细胞表型，尽管这显然不能通过改变 NHE 动力学来解释。
Defects of both sodium-hydrogen exchange (NHE) and sodium-lithium countertransport (SLC) have been described in subjects at increased risk of coronary heart disease (CHD). Sodium transport is linked to the regulation of cell volume, intracellular pH and cell growth, which may explain aspects of this association. However, impaired growth in early life is also linked to adult CHD, and 'programmed' alterations of cell behaviour are postulated to be responsible for this. In this study, therefore, we examined whether NHE or SLC in adults are predicted by anthropometric measures at birth, as well as being associated with insulin resistance syndrome (IRS) variables in adulthood. Red cell SLC was measured in 26 adults, and NHE in dermal fibroblasts from another 15 subjects characterized anthropometrically at birth. SLC activity correlated with LDL cholesterol, triglycerides and urate (r=0.42 - 0.49; 0.05 > P>0.01), but not birth anthropometry. NHE V(max) correlated with plasma insulin (r=0.80; P<0.001), but birth weight was unrelated to V(max), K(m) or Hill coefficient for H(i)(+). However, pH(i) correlated with birth weight (r=0.74; P=0.002), insulin sensitivity (r=0.52; P<0.05), fasting glucose (r=-0.52; P<0.05) 2 h insulin (r=0.51; P<0.05) 2 h glucose (r=-0.54; P<0.05). In conclusion, red cell SLC is related to IRS variables, but not with birth weight measures. In contrast, low intracellular pH(i) is related to both low birth weight and adult insulin resistance, suggesting it might be a 'programmed' cell phenotype, although this is not apparently explained by altered NHE kinetics.
红细胞钠锂反转运：原发性高血压和糖尿病之间的另一个联系。
影响因子：
3.2
作者：
Canessa,M
通讯作者：
Canessa,M