A prospective study of sleep duration and coronary heart disease in women
A prospective study of sleep duration and coronary heart disease in women
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DOI：
10.1001/archinte.163.2.205
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发表时间：
2003-01-27
影响因子：
--
通讯作者：
Hu, FB
中科院分区：
文献类型：
--
作者：
Ayas, NT;White, DP;Hu, FB
背景：长期睡眠剥夺在当今社会很常见。最近的实验表明，健康受试者的短期睡眠剥夺会导致不利的生理变化，包括葡萄糖耐量下降和血压升高。然而，长期睡眠不足对健康的长期影响尚不清楚。这项研究的目的是确定睡眠时间减少(来自自我报告)是否与冠状动脉事件风险增加相关。方法：我们研究了71617名参加护士健康研究的美国女性健康专业人员(年龄45-65岁)，她们在基线时没有报告患有冠心病。1986年，受试者被邮寄了一份问卷，询问他们每天的睡眠时间。受试者随访至1996年6月30日，观察冠心病相关事件的发生情况。我们评估了自我报告的睡眠时间与冠心病事件之间的关系。结果：在10年的随访中，共有934例冠状动脉事件被记录在案(271例死亡，663例非致命)。年龄调整后的相对危险度(95%可信区间)分别为1.82(1.342.41)、1.30(1.08-1.57)和1.06(0.89-1.26)。睡眠9小时或以上的相对危险度(95%可信区间)为1.57(1.18-2.11)。在调整了各种潜在的混杂因素，包括打鼾声、体重指数和吸烟后，报告睡眠时间不超过5小时、6小时和7小时的个体患冠心病的相对风险(95%可信区间)分别为1.45(1.10-1.92)、1.18(0.98-1.42)和1.09(0.91-1.30)。睡眠9小时或以上的相对危险度(95%可信区间)为1.38(1.03-1.86)。结论：自我报告的短睡眠时间和长睡眠时间独立地与冠状动脉事件的风险适度增加有关。
Background: Long-term sleep deprivation is common in today's society. Recent experiments have demonstrated that short-term sleep deprivation in healthy subjects results in adverse physiologic changes, including a decreased glucose tolerance and an increased blood pressure. However, the long-term health consequences of long-term sleep deprivation are unclear. The objective of this study was to determine whether decreased sleep duration (from self-reports) is associated with an increased risk of coronary events.Methods: We studied a cohort of 71617 US female health professionals (aged 45-65 years), without reported coronary heart disease (CHD) at baseline, who were enrolled in the Nurses' Health Study. Subjects were mailed a questionnaire in 1986 asking about daily sleep duration. Subjects were followed up until June 30, 1996, for the occurrence of CHD-related events. We assessed the relationship between self-reported sleep duration and incident CHD.Results: A total of 934 coronary events were documented (271 fatal and 663 nonfatal) during the 10 years of follow up. Age-adjusted relative risks (95% confidence intervals) of CHD (with 8 hours of daily sleep being considered the reference group) for individuals reporting 5 or fewer, 6, and 7 hours of sleep were 1.82 (1.342.41), 1.30 (1.08-1.57), and 1.06 (0.89-1.26), respectively. The relative risk (95% confidence interval) for 9 or more hours of sleep was 1.57 (1.18-2.11). After adjusting for various potential confounders, including snoring, body mass index, and smoking, the relative risks of CHD (95% confidence intervals) for individuals reporting 5 or fewer, 6, and 7 hours of sleep were 1.45 (1.10-1.92), 1.18 (0.98-1.42), and 1.09 (0.91-1.30), respectively. The relative risk (95% confidence interval) for 9 or more hours of sleep was 1.38 (1.03-1.86).Conclusion: Short and long self-reported sleep durations are independently associated with a modestly increased risk of coronary events.