Genesis, Evolution and Prevalence of H5N6 Avian Influenza Viruses in China
Genesis, Evolution and Prevalence of H5N6 Avian Influenza Viruses in China
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中国 H5N6 禽流感病毒的起源、进化和流行。
DOI：
10.1016/j.chom.2016.10.022
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发表时间：
2016-12-14
影响因子：
30.3
通讯作者：
Gao, George Fu
中科院分区：
文献类型：
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作者：
Bi, Yuhai;Chen, Quanjiao;Gao, George Fu
对活禽市场的持续监测是目前预测和识别对公共卫生构成潜在威胁的新出现的禽流感病毒的最佳方法。通过2014-2016年中国16个省市的LPM监测，我们确定了3，174份AIV阳性样本，并分离和测序了1，135株AIV，涵盖31种亚型。我们的分析表明，H5 N6已取代H5 N1成为中国南方，特别是鸭的AIV的优势亚型之一。系统发育分析表明，H5 N6来自H5和H6 N6病毒的重组，血凝素和神经氨酸酶的组合具有很强的谱系特异性。H5 N6病毒由至少34种不同的基因型组成，这些基因型源自不同的进化途径。值得注意的是，基因型G1.2病毒，其内部基因来自鸡H9 N2/H7N9基因库，是造成至少5例人类H5 N6感染的原因。我们的研究结果强调H5 N6禽流感病毒是对公共卫生和农业的潜在威胁。
Constant surveillance of live poultry markets (LPMs) is currently the best way to predict and identify emerging avian influenza viruses (AIVs) that pose a potential threat to public health. Through surveillance of LPMs from 16 provinces and municipalities in China during 2014-2016, we identified 3,174 AIV-positive samples and isolated and sequenced 1,135 AIVs covering 31 subtypes. Our analysis shows that H5N6 has replaced H5N1 as one of the dominant AIV subtypes in southern China, especially in ducks. Phylogenetic analysis reveals that H5N6 arose from reassortments of H5 and H6N6 viruses, with the hemagglutinin and neuraminidase combinations being strongly lineage specific. H5N6 viruses constitute at least 34 distinct genotypes derived from various evolutionary pathways. Notably, genotype G1.2 virus, with internal genes from the chicken H9N2/H7N9 gene pool, was responsible for at least five human H5N6 infections. Our findings highlight H5N6 AIVs as potential threats to public health and agriculture.