Riluzole is a radio-sensitizing agent in an in vivo model of brain metastasis derived from GRM1 expressing human melanoma cells.
Riluzole is a radio-sensitizing agent in an in vivo model of brain metastasis derived from GRM1 expressing human melanoma cells.
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DOI：
10.1111/pcmr.12327
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发表时间：
2015-01
影响因子：
4.3
通讯作者：
Chen S
中科院分区：
文献类型：
--
作者：
Wall BA;Yu LJ;Khan A;Haffty B;Goydos JS;Chen S
大约50%患有转移性黑色素瘤的患者在其疾病过程中发生脑转移。有证据表明，黑色素瘤细胞对电离辐射治疗引起的亚致死性DNA损伤的修复能力增强。为了解决黑色素瘤的放射抗性，许多小组采用了每天提供更大剂量辐射的放射治疗计划，但由于神经毒性的风险，这些大剂量辐射不能被输送到脑转移患者的整个大脑。在这里，我们使用原位植入表达GRM1的人黑色素瘤细胞异种移植物在小鼠中，以证明动物接受同时谷氨酸信号传导阻断（利鲁唑）和辐射导致颅内肿瘤生长减少相比，任何一种方式单独。这些临床前结果表明，利鲁唑可能会导致放射增敏，为接受脑转移放疗的一部分人黑色素瘤患者提供增强的疗效。
Approximately 50% of patients having metastatic melanoma develop brain metastases during the course of their illness. Evidence exists that melanoma cells have increased aptitude for the repair of sublethal DNA damage caused by ionizing radiation therapy. To address the radio-resistance of melanoma, many groups adopted radiotherapy schedules that deliver larger daily fractions of radiation, but due to the risk of neurotoxicity, these large fractions cannot be delivered to the whole brain for patients with brain metastases. Here, we used orthotopic implanted GRM1 expressing human melanoma cell xenografts in mice, to demonstrate that animals receiving concurrent glutamate signaling blockade (riluzole) and radiation led to a decrease in intracranial tumor growth compared to either modality alone. These preclinical results suggest riluzole may cause radiosensitization that offers enhanced efficacy for a subset of human melanoma patients undergoing radiotherapy for brain metastasis.
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DOI：
10.1158/1078-0432.ccr-10-1276
发表时间：
2011-04-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Khan AJ;Wall B;Ahlawat S;Green C;Schiff D;Mehnert JM;Goydos JS;Chen S;Haffty BG
通讯作者：
Haffty BG
影响因子：
30.8
作者：
Pollock, PM;Cohen-Solal, K;Chen, S
通讯作者：
Chen, S
DOI：
10.1158/1078-0432.ccr-11-0098
发表时间：
2011-11-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Lee HJ;Wall BA;Wangari-Talbot J;Shin SS;Rosenberg S;Chan JL;Namkoong J;Goydos JS;Chen S
通讯作者：
Chen S
影响因子：
6.5
作者：
Zhu, H;Reuhl, K;Chen, SZ
通讯作者：
Chen, SZ
影响因子：
9.9
作者：
Doble, A
通讯作者：
Doble, A