Prevalence and risk factors for esophageal squamous cell cancer and precursor lesions in Anyang, China: a population-based endoscopic survey.
Prevalence and risk factors for esophageal squamous cell cancer and precursor lesions in Anyang, China: a population-based endoscopic survey.
复制标题
中国安阳市食管鳞状细胞癌及其癌前病变的患病率和危险因素：基于人群的内镜调查。
DOI：
10.1038/sj.bjc.6605843
复制
发表时间：
2010-09-28
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
中国高发区食管鳞癌的病因尚不清楚。中国，对安阳市7381名25~65岁居民进行了胃镜活检。在这项研究中，2.57%、0.20%和0.16%的受试者分别患有轻度、中度和重度鳞状不典型增生；0.19%和0.08%的受试者表现为原位鳞癌和浸润性鳞癌。以深井(深度100m)为水源(优势比=0.72，95%可信区间：0.54~0.96)与ESCC及其前体呈负相关，而吸烟和饮酒与ESCC无显著相关。该地区的水源等因素还需要进一步的纵向研究进行评价。
The etiology of esophageal squamous cell cancer (ESCC) in high prevalence regions of China remains unclear. Endoscopic biopsies were conducted among 7381 inhabitants aged from 25 to 65 of Anyang, China. In this study, 2.57, 0.20 and 0.16% of the participants had mild, moderate and severe squamous dysplasia, respectively; 0.19 and 0.08% showed squamous carcinoma in situ and invasive ESCC. Using deep well (depth >100 meters) as water source (odds ratio=0.72, 95% confidence interval: 0.54–0.96) was negatively associated with ESCC and its precursors, whereas tobacco and alcohol use were not significantly associated with ESCC. Water source and other factors in this region need further evaluation by longitudinal studies.