Mechanical characterisation of the human thoracic descending aorta: experiments and modelling
Mechanical characterisation of the human thoracic descending aorta: experiments and modelling
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DOI：
10.1080/10255842.2010.520704
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发表时间：
2012-01-01
影响因子：
1.6
通讯作者：
Goicolea, Jose M.
中科院分区：
文献类型：
--
作者：
Garcia-Herrera, Claudio M.;Celentano, Diego J.;Goicolea, Jose M.
这项工作提出了实验和建模，旨在表征人体胸降主动脉的被动力学行为。为此，对对应于新生儿、年轻人和成人动脉的健康样本进行单轴拉伸和加压测试。然后，拉伸测量被用来校准的Holzapfel本构模型的材料参数。该模型被发现在很宽的变形范围内充分调整材料行为;特别是，它捕获了由于胶原纤维的拉伸而导致的渐进刚度增加和各向异性。最后，这些材料参数的评估在加压试验的建模中得到解决。本研究的意义是有可能预测人体胸降主动脉在一般负载状态（例如生理条件和/或医疗器械应用中可能发生的负载状态）下的机械响应。
This work presents experiments and modelling aimed at characterising the passive mechanical behaviour of the human thoracic descending aorta. To this end, uniaxial tension and pressurisation tests on healthy samples corresponding to newborn, young and adult arteries are performed. Then, the tensile measurements are used to calibrate the material parameters of the Holzapfel constitutive model. This model is found to adequately adjust the material behaviour in a wide deformation range; in particular, it captures the progressive stiffness increase and the anisotropy due to the stretching of the collagen fibres. Finally, the assessment of these material parameters in the modelling of the pressurisation test is addressed. The implication of this study is the possibility to predict the mechanical response of the human thoracic descending aorta under generalised loading states like those that can occur in physiological conditions and/or in medical device applications.