Annexin A11 in disease
Annexin A11 in disease
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疾病中的膜联蛋白 A11
DOI：
10.1016/j.cca.2014.01.031
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发表时间：
2014-04-20
影响因子：
5
通讯作者：
Greenaway, Frederick T.
中科院分区：
文献类型：
--
作者：
Wang, Jiasheng;Guo, Chunmei;Greenaway, Frederick T.
膜联蛋白A11（Annexin A11，Anxa 11）是钙离子调节的磷脂依赖性膜结合膜联蛋白多基因家族的成员，广泛表达于多种细胞类型。研究表明Anxa 11在细胞分裂、Ca 2+信号转导、囊泡运输和凋亡中发挥重要作用。Anxa 11的失调控和突变与系统性自身免疫性疾病、结节病以及癌症的发生、耐药性和复发有关。Anxa 11的功能异常可能通过血小板衍生生长因子受体（PDGFR）通路和/或丝裂原活化蛋白激酶（MAPK）/p53通路导致或增强癌症的转移、侵袭和耐药性。在多种疾病中，Anxa 11最常被报道通过与阿尔茨海默病相关基因-2蛋白（ALG-2）和/或钙周期蛋白（S100 A6）相互作用发挥作用。尽管对Anxa 11的研究很少，但它是一种很有前途的生物标志物，可用于某些疾病的诊断、治疗和预后。本文就Anxa 11与Ca ~（2+）调节的胞吐、胞质分裂、性别分化、自身免疫性疾病、血栓溶解和癌症的关系作一综述。(C)2014爱思唯尔有限公司版权所有。
Ubiquitously expressed in many cell types, annexin A11 (Anxa11) is a member of the multigene family of Ca2+-regulated phospholipid-dependent and membrane-binding annexin proteins. Studies have shown that Anxa11 plays an important role in cell division, Ca2+ signaling, vesicle trafficking and apoptosis. The deregulation and mutation of Anxa11 are involved in systemic autoimmune diseases, sarcoidosis and the development, chemoresistance and recurrence of cancers. Malfunction of Anxa11 may lead to or enhance the metastasis, invasion and drug resistance of cancers through the platelet-derived growth factor receptor (PDGFR) pathway and/or the mitogen-activated protein kinase (MAPK)/p53 pathway. In a variety of diseases, Anxa11 is most commonly reported to function through interactions with apoptosis-linked gene-2 protein (ALG-2) and/or calcyclin (S100A6). Although it has been little studied, Anxa11 is a promising biomarker for the diagnosis, treatment and prognosis of certain diseases. In this review, the associations of Anxa11 with Ca2+-regulated exocytosis, cytokinesis, sex differentiation, autoimmune diseases, thrombolysis and cancers are summarized and interpreted. (C) 2014 Elsevier B.V. All rights reserved.