Distribution of pertussis antibodies among different age groups in Japan
Distribution of pertussis antibodies among different age groups in Japan
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DOI：
10.1016/s0264-410x(02)00045-2
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发表时间：
2002-03-15
期刊：
影响因子：
5.5
通讯作者：
Matsunaga, Y
中科院分区：
文献类型：
--
作者：
Konda, T;Kamachi, K;Matsunaga, Y
我们研究了分布的抗体水平对百日咳毒素（PT）和丝状血凝素（FHA）在一个健康的日本人口年龄从0到77岁。用聚苯乙烯球ELISA法检测了1994年9个地市1108份血清中两种抗体的水平。随着接种3次以上无细胞百日咳（R）疫苗人群的增加，0 - 3岁年龄段抗PT和抗FHA抗体阳性（大于或等于10 ELISA U/ml）的个体比例迅速增加。然而，在接种人群中，抗PT抗体阳性的比例在6-8岁之前趋于下降，在9 - 19岁之间再次增加，尽管在3岁以上的儿童和青少年中，抗FHA抗体阳性的个体比例保持在80-100%。此外，在从青少年和年轻人收集的一些血清样本中，抗PT抗体阳性率较高（：50 ELISA U/ml），表明近期有症状或无症状感染了循环百日咳杆菌。另一方面，50-60%的12月龄以下婴儿的抗PT和抗FHA抗体低于检测限（1.0 ELISA U/ml），大多数早期婴儿未接种百日咳疫苗。由于B.尽管日本人中仍存在百日咳，但应强烈建议所有婴儿接种aP疫苗以预防百日咳。(C)2002爱思唯尔科技有限公司版权所有。
We examined the distribution of antibody levels against pertussis toxin (PT) and filamentous hemagglutinin (FHA) among a healthy Japanese population aged from 0 to 77 years. Levels of both antibodies in 1108 serum samples collected in 1994 from nine prefectures were assayed using polystyrene ball ELISA. The ratio of individuals positive ( greater than or equal to10 ELISA U/ml) for anti-PT and anti-FHA antibodies at ages ranging from 0 to 3 years increased rapidly with the increase in the population vaccinated over three times with acellular pertussis (R) vaccine. However, the ratio of those positive for anti-PT antibody tended to decrease until 6-8 years of age and to increase again from 9 to 19 years among; the vaccinated population, although the ratio of individuals positive for anti-FHA antibody remained constant at 80-100% in children and adolescents over 3 years old. Moreover, positivity for anti-PT antibody was high ( :50 ELISA U/ml) in some serum samples collected from adolescents and young adults, suggesting recent symptomatic or asymptomatic infection with circulating Bordetella pertussis. On the other hand, 50-60% of infants below 12 months of age was below the detection limit (1.0 ELISA U/ml) for anti-PT and anti-FHA antibodies, and most early infants were not vaccinated for pertussis. Since intermittent circulation of B. pertussis remains among the Japanese population, complete vaccination with aP vaccine for all infants should be highly recommended to prevent pertussis. (C) 2002 Elsevier Science Ltd. All rights reserved.