Changes in Cerebral Blood Flow and Oxygenation During Induction of General Anesthesia with Sevoflurane Versus Propofol
Changes in Cerebral Blood Flow and Oxygenation During Induction of General Anesthesia with Sevoflurane Versus Propofol
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DOI：
10.1007/978-1-4939-3023-4_60
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发表时间：
2016-01-01
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影响因子：
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通讯作者：
Katayama, Yoichi
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作者：
Kondo, Yuko;Hirose, Noriya;Katayama, Yoichi
七氟醚和异丙酚被广泛用于全身麻醉的诱导和维持。虽然七氟醚和异丙酚对维持全麻期间脑血流动力学的影响已被证实，但在全麻诱导期间的影响仍未明确。因此，我们比较了七氟醚（S组：n = 9）和异丙酚（P组：n = 9）诱导麻醉时脑血流量（CBF）和氧合（CBO）的变化。使用以下变量评估CBF和CBO：氧、脱氧和总血红蛋白（Hb）浓度和组织氧指数（TOI），通过近红外光谱测量前额。在给药七氟醚或异丙酚前和给药诱导剂后4分钟内每10秒记录一次这些变量。S组患者通过麻醉面罩给予8%七氟醚和100%氧气，P组患者在氧合期间静脉注射2mg /kg异丙酚。我们发现S组的氧合血红蛋白、总血红蛋白和TOI明显高于P组（P < 0.05）。deoxy-Hb、MBP和HR的变化在两组之间没有差异。本研究结果表明，七氟醚可增加全身麻醉诱导时的CBF和CBO。
Sevoflurane and propofol are widely used for induction and maintenance of general anesthesia. Although the effects of sevoflurane and propofol on cerebral hemodynamics during maintenance of general anesthesia have been demonstrated, the effects during induction of general anesthesia have still not been clarified. We therefore compared changes in cerebral blood flow (CBF) and oxygenation (CBO) during induction of anesthesia using sevoflurane (group S: n = 9) or propofol (group P: n = 9). CBF and CBO were evaluated using the following variables: oxy-, deoxy-, and total-hemoglobin (Hb) concentrations and tissue oxygen index (TOI), measured on the forehead by near-infrared spectroscopy. The variables were recorded immediately before administration of sevoflurane or propofol and at every 10 s for 4 min after administration of the induction agent. Patients received 8 % sevoflurane in 100 % oxygen via an anesthesia mask in group S, and an IV bolus of 2 mg/kg of propofol during oxygenation in group P. We found that oxy-Hb, total-Hb, and TOI were significantly higher in group S than in group P (P> 0.05). Changes in deoxy-Hb, MBP, and HR did not differ between the groups. The results of the present study demonstrated that sevoflurane increases CBF and CBO during induction of general anesthesia.