STUDIES ON PARACETAMOL BINDING TO SERUM-PROTEINS
STUDIES ON PARACETAMOL BINDING TO SERUM-PROTEINS
复制标题
DOI：
10.1177/000456329403100512
复制
发表时间：
1994-09-01
影响因子：
2.2
通讯作者：
PRICE, CP
中科院分区：
文献类型：
--
作者：
MILLIGAN, TP;MORRIS, HC;PRICE, CP
关于扑热息痛与血浆蛋白结合的数据有限。有人认为，结合可能会影响一些分析方法的能力，以定量的血浆组分中存在的药物总量的风险评估和解毒剂使用的临床经验的基础。我们使用超滤技术研究了对乙酰氨基酚与血浆蛋白的结合。在过量和加标尿毒症血浆样本中，对乙酰氨基酚结合的平均百分比为24.1（1SD = 7.0），与药物水平或尿毒症程度无显著相关性。随着血清白蛋白浓度的增加，血浆（r（s）= 0.549，P = 0.014）和纯血清白蛋白溶液（r（s）= 0.848，P < 0.001）中的结合率都有小幅但显著的增加。
There is a limited amount of data on the binding of paracetamol to plasma proteins. It has been suggested that binding might influence the ability of some analytical methods to quantify the total amount of drug present in the plasma fraction-the basis of clinical experience in risk assessment and antidote usage. We have investigated the binding of paracetamol to plasma proteins using an ultrafiltration technique. In overdose and spiked uraemic plasma samples the mean percentage of paracetamol bound was 24.1 (1SD = 7.0) with no significant correlation with drug levels or degree of uraemia. There is a small but significant increase in binding with increasing serum albumin concentration both in plasma (r(s) = 0.549, P = 0.014) and in pure serum albumin solutions (r(s) = 0.848, P < 0.001).