Detection of acute renal ischemia in swine using blood oxygen level-dependent magnetic resonance imaging
Detection of acute renal ischemia in swine using blood oxygen level-dependent magnetic resonance imaging
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DOI：
10.1002/jmri.20389
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发表时间：
2005-09-01
影响因子：
4.4
通讯作者：
Grist, TM
中科院分区：
文献类型：
--
作者：
Alford, SK;Sadowski, EA;Grist, TM
目的：建立猪急性肾缺血模型，探讨血氧水平依赖磁共振成像(BOLD)检测急性肾缺血的可行性和敏感性，提出变异的原因，并评估在数据分析中引入的最小化变异的技术。材料和方法：对5只猪的肾脏进行轴位和冠状平面的BOLD磁共振成像。计算彩色R2*图，并确定基线、肾动脉阻断和再灌流条件下皮质和髓质的平均R2*值和95%可信区间(CI)。结果：肾动脉闭塞时肾动脉皮质(轴向，13.8-24.6秒(-1)；冠状，14.4-24.7秒(-1))和髓质(轴向，19.3-32.2秒(-1)：冠状，20.1-30.7秒(-1))的R2*测量值均较术前增加。这些差异在皮质(轴向P<；0.04；冠状，P<；0.005)和髓质(轴向，P<；0.02；冠状，P<；0.0005)方面都有显著差异。对侧肾脏无明显变化。结论：肾动脉阻断时，肾髓质和皮质的R2*值显著高于基线。在髓质的R2*测量中存在比皮质更大的变异性，在轴向比冠状平面存在更多的变异性。
Purpose: To determine the feasibility and sensitivity of blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) to detect acute renal ischemia, using a swine model, and to present the causes of variability and assess techniques that minimize variability introduced during data analysis.Materials and Methods: BOLD MRI was performed in axial and coronal planes of the kidneys of five swine. Color R2* maps were calculated and mean R2* values and 95% confidence intervals (CIs) for the cortex and medulla were determined for baseline, renal artery occlusion and reperfusion conditions. Paired Student's t-tests were used to determine significance.Results: Mean R2* measurements increased from baseline during renal artery occlusion in the cortex (axial, 13.8-24.6 second(-1); coronal, 14.4-24.7 second(-1)) and medulla (axial, 19.3-32.2 second(-1): coronal, 20.1-30.7 second(-1)). These differences were significant for both the cortex (axial, P < 0.04; coronal, P < 0.005) and medulla (axial, P < 0.02; coronal, P < 0.0005). No significant change was observed in the contralateral kidney.Conclusion: R2* values were significantly higher than baseline for medulla and cortex during renal artery occlusion. More variability exists in R2* measurements in the medulla than the cortex and in the axial than the coronal plane.