PROTECTIVE EFFECT OF ARTIFICIALLY INDUCED HIBERNATION AGAINST LETHAL DOSES OF WHOLE BODY X-IRRADIATION IN CF1 MALE MICE
PROTECTIVE EFFECT OF ARTIFICIALLY INDUCED HIBERNATION AGAINST LETHAL DOSES OF WHOLE BODY X-IRRADIATION IN CF1 MALE MICE
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DOI：
10.1152/ajplegacy.1959.196.6.1211
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发表时间：
1959-01-01
影响因子：
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通讯作者：
RUGH, R
中科院分区：
文献类型：
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作者：
KUSKIN, SM;WANG, SC;RUGH, R
低温诱导使用神经麻痹药物，如喜得镇，氯丙嗪或异丙嗪，随后由冷藏，并没有显着提高保护作用提供的冷藏单独对致死剂量的全身X射线照射的CF 1雄性小鼠。没有冷藏的神经麻痹药物提供轻微程度的保护，可能是由于体温的轻微降低。看来，体温过低作为一种保护机制的作用不仅取决于新陈代谢的抑制，而且取决于身体过程的普遍抑制。氨基甲酸乙酯，与冷藏，似乎增加了X-照射的致死作用的CF 1品系的雄性小鼠。
Hypothermia induced by the use of neuroplegic drugs such as Hydergine, chlorpromazine or promethazine, followed by refrigeration, does not significantly enhance the protective action afforded by refrigeration alone against the letal dose of whole body x-irradiation in CF1 male mice. The neuroplegic drugs, without refrigeration, provide a slight degree of protection, probably due to the slight reduction in the body temperature. It appears that the action of hypothermia as a protective mechanism depends not on depression of metabolism alone, but on a general depression of bodily processes. Urethane, in conjunction with refrigeration, appears to augment the lethal effect of x-irradiation in the CF1 strain of male mice.