Aggressive jejunal lymphoma of large granular lymphocytes. Immunohistochemical, ultrastructural, molecular, and DNA content analysis.
Aggressive jejunal lymphoma of large granular lymphocytes. Immunohistochemical, ultrastructural, molecular, and DNA content analysis.
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大颗粒淋巴细胞的侵袭性空肠淋巴瘤。
DOI：
10.1093/ajcp/93.1.124
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发表时间：
1990
影响因子：
3.5
通讯作者：
D. Clark
中科院分区：
文献类型：
--
作者：
T. Longacre;M. Listrom;J. Spigel;C. Willman;L. Dressler;D. Clark
An unusual large cell lymphoma of the proximal jejunum with large granular lymphocyte (LGL) morphologic characteristics and T-helper/inducer cell phenotype is described. Although the cells strongly expressed Leu-7 (HNK-1), studies with antibodies directed against the more specific natural killer (NK) antigens, CD16 (Leu-11) and Leu-19, were negative. Ultrastructural analysis of the neoplastic cells demonstrated substantial numbers of electron-dense granules and rare parallel tubular arrays. Clonal rearrangement of the T-cell receptor beta chain gene and germline configuration of the immunoglobulin heavy chain gene confirmed the T-cell origin of the neoplastic cells. This lymphoma pursued an aggressive clinical course, with rapid dissemination to the lungs and central nervous system. DNA content analysis indicated that a similar DNA aneuploid population was present in the jejunal primary and lung tissue at recurrence. There was no evidence of nodal, peripheral blood, splenic, or bone marrow involvement. Morphologic and functional similarities between the lymphoid tissues of the gastrointestinal tract and lung have previously prompted a classification of the immune system into distinct peripheral somatic and mucosal components. Based on the distribution and migratory properties of the tumor cells in this case, the authors propose that this lymphoma arose from a minor mucosa-associated LGL subset that may be unrelated to circulating LGLs. In addition, these observations emphasize that prominent granulated cytomorphologic features may be seen in neoplastic disorders with the T-helper/inducer phenotype, as well as in the more widely recognized lymphoproliferative disorders of NK and cytotoxic/suppressor cell types.
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大颗粒淋巴细胞白血病中 T 细胞受体基因的重排和表达。
影响因子：
20.3
作者：
LoughranJr,TP;Starkebaum,G;Aprile,JA
通讯作者：
Aprile,JA
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影响因子：
20.3
作者：
Pelicci,PG;Allavena,P;Subar,M;Rambaldi,A;Pirelli,A;DiBello,M;Barbui,T;Knowles2nd,DM;Dalla-Favera,R;Mantovani,A
通讯作者：
Mantovani,A
通过流式细胞术评估乳腺癌 S 期建模系统的评估。
影响因子：
11.2
作者：
Dressler,LG;Seamer,L;Owens,MA;Clark,GM;McGuire,WL
通讯作者：
McGuire,WL
使用单克隆抗体对人小肠粘膜淋巴细胞进行免疫组织学和免疫电镜表征。
DOI：
--
发表时间：
1983
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Cerf-Bensussan,N;Schneeberger,EE;Bhan,AK
通讯作者：
Bhan,AK