Editorial Focus: PPAR (cid:1) differentially regulates energy substrate handling in brown vs. white adipose : focus on “The PPAR (cid:1) agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake”
Editorial Focus: PPAR (cid:1) differentially regulates energy substrate handling in brown vs. white adipose : focus on “The PPAR (cid:1) agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake”
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编辑焦点：PPAR (cid:1) 差异调节棕色脂肪与白色脂肪中的能量底物处理：重点关注“PPAR (cid:1) 激动剂罗格列酮增强大鼠棕色脂肪组织从葡萄糖中的脂肪生成，而不改变葡萄糖摄取”
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
M. Ryan
中科院分区：
文献类型：
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作者：
J. Grobe;Marcia Venegas‐Pont;C. Sigmund;M. Ryan
过氧化物酶体增殖物 - 激活受体 (cid:1) (PPAR (cid:1)) 是一种核受体和配体激活转录因子，在棕色脂肪组织 (BAT) 中高度表达，是其发育所必需的 (1,6,7)。 BAT 因其在啮齿类动物代谢率控制方面的功能而得到广泛认可 (2)，最近的研究也在成年人体内发现了大量的 BAT (9)。 BAT 表现出相对较高的脂质和葡萄糖摄取率，并通过脂质氧化和解偶联蛋白 1 的激活，响应交感神经激活和其他刺激而产生大量热量。在脂肪细胞中，脂肪酸以三酰甘油（TAG）的形式储存。鉴于该组织的高代谢活性，细胞内 TAG 合成和储存的调节对于 BAT 的正常功能非常重要。
PEROXISOME PROLIFERATOR - ACTIVATED receptor (cid:1) (PPAR (cid:1) ) is a nuclear receptor and ligand-activated transcription factor that is highly expressed in brown adipose tissue (BAT) and is neces-sary for its development (1, 6, 7). BAT is well recognized for its functions in metabolic rate control in rodents (2), and recent work has also identified significant amounts of BAT in adult humans (9). BAT exhibits relatively high rates of lipid and glucose uptake, and generates significant heat in response to sympathetic activation and other stimuli through lipid oxida-tion and activation of uncoupling protein-1. In adipocytes, fatty acids are stored as triacylglycerol (TAG). Given the high metabolic activity of this tissue, the regulation of intracellular synthesis and storage of TAG is of great importance for normal BAT function.
影响因子：
4.8
作者：
Festuccia, William T.;Oztezcan, Serdar;Deshaies, Yves
通讯作者：
Deshaies, Yves