Distinct deletions of chromosome 9p associated with melanoma versus glioma, lung cancer, and leukemia.
Distinct deletions of chromosome 9p associated with melanoma versus glioma, lung cancer, and leukemia.
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发表时间：
1994-01
期刊：
影响因子：
11.2
通讯作者：
A. Coleman;J. Fountain;T. Nobori;O. Olopade;Gavin P. Robertson;D. Housman;T. Lugo
中科院分区：
文献类型：
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作者：
A. Coleman;J. Fountain;T. Nobori;O. Olopade;Gavin P. Robertson;D. Housman;T. Lugo
染色体9p21-22上的DNA缺失常见于黑色素瘤、神经胶质瘤、非小细胞肺癌和急性淋巴细胞性白血病。后三种癌症共有的最小缺失从干扰素-α基因延伸到着丝粒；其着丝粒末端由编码甲基硫代腺苷磷酸化酶的基因组成。我们已经确定，两个黑色素瘤细胞系共有的最小纯合缺失的端粒末端不包括甲基硫代腺苷磷酸化酶基因座。因此，在黑色素瘤中，DNA的一个独特区域丢失。这个区域的物理大小仍有待精确定义，但它可能会延伸到数百万个碱基对以上。
Deletions of DNA on chromosome 9p21-22 are frequently observed in cells derived from melanomas, gliomas, non-small cell lung cancers, and acute lymphoblastic leukemia. The minimal deletion shared by the latter three cancers extends from the interferon-alpha locus towards the centromere; its centromeric end is flanked by the gene encoding methylthioadenosine phosphorylase. We have determined that the telomeric end of the minimal homozygous deletion shared by two melanoma cell lines does not include the methylthioadenosine phosphorylase locus. Thus, a distinct region of DNA is lost in melanoma. The physical size of this region remains to be defined precisely, but it may extend over several million base pairs.