SUSCEPTIBILITY OF ANAEROBIC BACTERIA TO METRONIDAZOLE - RELATIVE RESISTANCE OF NON-SPORE-FORMING GRAM-POSITIVE BACCILLI
SUSCEPTIBILITY OF ANAEROBIC BACTERIA TO METRONIDAZOLE - RELATIVE RESISTANCE OF NON-SPORE-FORMING GRAM-POSITIVE BACCILLI
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DOI：
10.1093/infdis/131.2.182
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发表时间：
1975-01-01
影响因子：
6.4
通讯作者：
GUZE, LB
中科院分区：
文献类型：
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作者：
CHOW, AW;PATTEN, V;GUZE, LB
采用琼脂稀释法测定了358株临床分离的专性厌氧菌对甲硝唑的敏感性。只有66%的所有分离株被6.25 μg/ml抑制，而30%需要≥ 50 μg/ml。不同属、种间的敏感性差异较大，梭杆菌属最敏感，其次为梭菌属、拟杆菌属、消化球菌属、消化链球菌属、韦荣氏球菌属、Addaminococcus和非芽孢革兰氏阳性杆菌，拟杆菌属中金黄色拟杆菌的敏感性最高。同样，Clostridium perjringens比Clostridium的其他物种更敏感。甲硝唑是治疗梭菌属、梭菌属和B.脆性，其他厌氧菌感染的治疗应以体外敏感性试验为指导。
Susceptibility of 358 clinical isolates of obligate anaerobes to metronidazole was determined by an agar-dilution technique. Only 66% of all isolates were inhibited by 6.25 µg/ml, whereas 30% required ≥ 50 µg/ml. Considerable variation in susceptibility was observed among different genera and species of bacteria.Fusobacteriumwas most sensitive, followed byClostridium, BacteroidesandPeptococcus, Peptostreptococcus, VeillonellaandAddaminococcus, and non-sporeforming gram-positive bacilli.Bacteroides jragiliswas more sensitive than other species ofBacteroides. Similarly,Clostridium perjringenswas more susceptible than other species ofClostridium. While metronidazole appears to be a promising antimicrobial agent for infections caused byFusobacterium, Clostridium, andB. Fragilis, therapy for infections with other anaerobic bacteria should be guided by in vitro tests of sensitivity.