Increased chromosome aberration frequencies in the Bowen's patients compared to non-cancerous skin lesions individuals exposed to arsenic
Increased chromosome aberration frequencies in the Bowen's patients compared to non-cancerous skin lesions individuals exposed to arsenic
复制标题
DOI：
10.1016/j.mrgentox.2007.05.005
复制
发表时间：
2007-08-15
影响因子：
1.9
通讯作者：
Giri, Ashok K.
中科院分区：
文献类型：
--
作者：
Ghosh, Pritha;Banerjee, Mayukh;Giri, Ashok K.
细胞遗传学生物标志物对于评估环境暴露至关重要，可以预测对人类健康的不利影响，例如细胞损伤。染色体畸变是最重要的细胞遗传学终点，成功地用于职业或环境暴露于不同有毒化学品的人群的癌症风险评估。以往的研究表明，外周血淋巴细胞中染色体畸变（CA）频率的增加是癌症的预测因子。砷是一种矛盾的人类致癌物，染色体断裂剂和非整倍体。尽管暴露在类似的程度，只有15-20%的人显示砷诱导的皮肤病变，包括鲍温病（BD）。以前，我们已经报道了显着增加CA的个人与砷引起的皮肤病变相比，没有任何皮肤病变的个人，饮用砷污染的水在类似的程度。目前，进行了一项配对病例对照研究，以检查是否生物标志物，如染色体畸变可以预测砷诱导的Bowen病（原位癌）的发展。本文分析了25例Bowen病患者的淋巴细胞染色体畸变（包括染色体和染色单体类型）和有丝分裂指数，并与砷中毒引起的非癌性皮肤病变（如雨滴色素沉着、掌跖角化、色素减退和色素增多）的对照组进行了比较。与对照组相比，病例组的染色体畸变/细胞、染色体类型畸变和畸变细胞的总百分比显著更高（p < 0.01）。这些结果表明，染色体畸变可以用于癌症的风险评估人群通过饮用水砷暴露。(c)2007 Elsevier B. V.保留所有权利。
Cytogenetic biomarkers are essential for assessing environmental exposure that can predict adverse human health effects such as cellular damage. Chromosomal aberrations are the most important cytogenetic end-points successfully used for the cancer risk assessment of populations occupationally or environmentally exposed to different toxic chemicals. Previous reports suggest that, increased frequency of chromosomal aberration (CA), in peripheral blood lymphocytes, is a predictor of cancer. Arsenic is a paradoxical human carcinogen, clastogen and aneugen. Despite of exposure at similar extent, only 15-20% of individuals show arsenic induced skin lesions including Bowen's disease (BD). Previously we have reported the significant increase in CA in the individuals with arsenic induced skin lesions when compared to individuals without any skin lesions, drinking arsenic contaminated water at similar extent. Presently, a matched case-control study was performed to examine whether biomarkers such as chromosomal aberrations can predict the development of arsenic induced Bowen's (in situ carcinoma) diseases. Chromosomal aberrations (both chromosome and chromatid types) and mitotic index were analyzed from the lymphocytes of 25 cases of Bowen's patient which was compared to matched control from the individuals with arsenic induced non-cancerous skin lesions such as raindrop pigmentation, keratosis of palm and sole, hypo and hyper pigmentation. Chromosomal aberrations/cell, chromosome type aberrations and total percentage of aberrant cells were significantly higher in cases compared to control (p < 0.01). These results suggest that chromosomal aberrations can be used for cancer risk assessment of the population exposed to arsenic through drinking water. (c) 2007 Elsevier B.V. All rights reserved.